Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-05-28T04:27:16Z | - |
dc.date.available | 2018-05-28T04:27:16Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | BIOMATERIALS, v. 87, Page. 118-130 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961216001289?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71550 | - |
dc.description.abstract | Metastasis, the primary cause of tumor cell transformation, is often activated during cancer invasion and progression and is associated with poor therapeutic outcomes. The effects of combined treatments that included PEG-coated gold nanoparticles (GNP) and cold plasma on epithelial-mesenchymal transition (EMT) and the maintenance of cancer stem cells (CSC) have not been described so far. Here, we report that co-treatment with GNP and cold plasma inhibited proliferation in cancer cells by abolishing the activation of the PI3K/AKT signaling axis. In addition, co-treatment reversed EMT in solid tumor cells by reducing the secretion of a number of proteins, resulting in the upregulation of epithelial markers such as E-cadherin along with down-regulation of N-Cadherin, Slug and Zeb-1. The inhibition of the PI3K/AKT pathway and the reversal of EMT by co-treatment prevented tumor cells growth in solid tumors. Furthermore, we show that GNP and plasma also suppresses tumor growth by decreasing mesenchymal markers in tumor xenograft mice models. Importantly, co-treatment resulted in a substantial decrease in sphere formation and the self-renewal capacity of glioma-like stem cells. Together, these results indicate a direct link between a decrease of EMT and an increase in cell death in solid tumors following co treatment with cold plasma and GNP. (C) 2016 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation of Korea (NRF), which is funded by the Korean Government, Ministry of Science, ICT and Future Planning (MSIP) (NRF-2010-0027963), and through its National Nuclear Technology Program (NRF-2015M2A2A7A01044998). This work also partially supported by Kwangwoon University in 2016. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Cold plasma | en_US |
dc.subject | Gold nanoparticles | en_US |
dc.subject | Solid cancers | en_US |
dc.subject | Stemness | en_US |
dc.subject | Glioma-like stem cells | en_US |
dc.subject | Epithelial-mesenchymal transition | en_US |
dc.title | Low doses of PEG-coated gold nanoparticles sensitize solid tumors to cold plasma by blocking the PI3K/AKT-driven signaling axis to suppress cellular transformation by inhibiting growth and EMT | en_US |
dc.type | Article | en_US |
dc.relation.volume | 87 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2016.02.014 | - |
dc.relation.page | 118-130 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Kaushik, Nagendra Kumar | - |
dc.contributor.googleauthor | Kaushik, Neha | - |
dc.contributor.googleauthor | Yoo, Ki Chun | - |
dc.contributor.googleauthor | Uddin, Nizam | - |
dc.contributor.googleauthor | Kim, Ju Sung | - |
dc.contributor.googleauthor | Lee, Su Jae | - |
dc.contributor.googleauthor | Choi, Eun Ha | - |
dc.relation.code | 2016001577 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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