Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송순영 | - |
dc.date.accessioned | 2018-05-28T01:51:35Z | - |
dc.date.available | 2018-05-28T01:51:35Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | KOREAN JOURNAL OF RADIOLOGY, v. 17, NO 3, Page. 330-338 | en_US |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.issn | 2005-8330 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2016.17.3.330 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/71542 | - |
dc.description.abstract | Objective: This multi-center, randomized, double-blind, phase 3 trial was conducted to compare the safety and efficacy of contrast agents iohexol-380 and iohexol-350 for coronary CT angiography in healthy subjects. Materials and Methods: Volunteers were randomized to receive 420 mgI/kg of either iohexol-350 or iohexol-380 using a flow rate of 4 mL/sec. All adverse events were recorded. Two blinded readers independently reviewed the CT images and conflicting results were resolved by a third reader. Luminal attenuations (ascending aorta, Left main coronary artery, and Left ventricle) in Hounsfield units (HUs) and image quality on a 4-point scale were calculated. Results: A total of 225 subjects were given contrast media (115 with iohexol-380 and 110 with iohexoL-350). There was no difference in number of adverse drug reactions between groups: 75 events in 56 (48.7%) of 115 subjects in the iohexol-380 group vs. 74 events in 51 (46.4%) of 110 subjects in the iohexol-350 group (p = 0.690). No severe adverse drug reactions were recorded. Neither group showed an increase in serum creatinine. Significant differences in mean density between the groups was found in the ascending aorta: 375.8 71.4 HU with iohexol-380 vs. 356.3 61.5 HU with iohexoL-350 (p = 0.030). No significant differences in image quality scores between both groups were observed for all three anatomic evaluations (all, p ˃ 0.05). Conclusion: Iohexol-380 provides improved enhancement of the ascending aorta and similar attenuation of the coronary arteries without any increase in adverse drug reactions, as compared with iohexol-350 using an identical amount of total iodine. | en_US |
dc.description.sponsorship | This study was supported by grant no. 06-2012-2140 from the Central Medical Service (CMS) Research Fund. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN RADIOLOGICAL SOC | en_US |
dc.subject | Coronary arteries | en_US |
dc.subject | Contrast media | en_US |
dc.subject | Contrast materials | en_US |
dc.subject | Drug safety | en_US |
dc.subject | Image quality enhancement | en_US |
dc.title | Comparison of Iohexol-380 and Iohexol-350 for Coronary CT Angiography: A Multicenter, Randomized, Double-Blind Phase 3 Trial | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 17 | - |
dc.identifier.doi | 10.3348/kjr.2016.17.3.330 | - |
dc.relation.page | 330-338 | - |
dc.relation.journal | KOREAN JOURNAL OF RADIOLOGY | - |
dc.contributor.googleauthor | Park, Eun-Ah | - |
dc.contributor.googleauthor | Lee, Whal | - |
dc.contributor.googleauthor | Kang, Doo Kyoung | - |
dc.contributor.googleauthor | Kim, Sung Jin | - |
dc.contributor.googleauthor | Kim, Young-Ju | - |
dc.contributor.googleauthor | Kim, Yookyung | - |
dc.contributor.googleauthor | Sung, Yon Mi | - |
dc.contributor.googleauthor | Song, Soon-Young | - |
dc.contributor.googleauthor | Oh, Yu-Whan | - |
dc.contributor.googleauthor | Yong, Hwan Seok | - |
dc.relation.code | 2016010597 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | songsy | - |
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