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dc.contributor.author송순영-
dc.date.accessioned2018-05-28T01:51:35Z-
dc.date.available2018-05-28T01:51:35Z-
dc.date.issued2016-05-
dc.identifier.citationKOREAN JOURNAL OF RADIOLOGY, v. 17, NO 3, Page. 330-338en_US
dc.identifier.issn1229-6929-
dc.identifier.issn2005-8330-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2016.17.3.330-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/71542-
dc.description.abstractObjective: This multi-center, randomized, double-blind, phase 3 trial was conducted to compare the safety and efficacy of contrast agents iohexol-380 and iohexol-350 for coronary CT angiography in healthy subjects. Materials and Methods: Volunteers were randomized to receive 420 mgI/kg of either iohexol-350 or iohexol-380 using a flow rate of 4 mL/sec. All adverse events were recorded. Two blinded readers independently reviewed the CT images and conflicting results were resolved by a third reader. Luminal attenuations (ascending aorta, Left main coronary artery, and Left ventricle) in Hounsfield units (HUs) and image quality on a 4-point scale were calculated. Results: A total of 225 subjects were given contrast media (115 with iohexol-380 and 110 with iohexoL-350). There was no difference in number of adverse drug reactions between groups: 75 events in 56 (48.7%) of 115 subjects in the iohexol-380 group vs. 74 events in 51 (46.4%) of 110 subjects in the iohexol-350 group (p = 0.690). No severe adverse drug reactions were recorded. Neither group showed an increase in serum creatinine. Significant differences in mean density between the groups was found in the ascending aorta: 375.8 71.4 HU with iohexol-380 vs. 356.3 61.5 HU with iohexoL-350 (p = 0.030). No significant differences in image quality scores between both groups were observed for all three anatomic evaluations (all, p ˃ 0.05). Conclusion: Iohexol-380 provides improved enhancement of the ascending aorta and similar attenuation of the coronary arteries without any increase in adverse drug reactions, as compared with iohexol-350 using an identical amount of total iodine.en_US
dc.description.sponsorshipThis study was supported by grant no. 06-2012-2140 from the Central Medical Service (CMS) Research Fund.en_US
dc.language.isoenen_US
dc.publisherKOREAN RADIOLOGICAL SOCen_US
dc.subjectCoronary arteriesen_US
dc.subjectContrast mediaen_US
dc.subjectContrast materialsen_US
dc.subjectDrug safetyen_US
dc.subjectImage quality enhancementen_US
dc.titleComparison of Iohexol-380 and Iohexol-350 for Coronary CT Angiography: A Multicenter, Randomized, Double-Blind Phase 3 Trialen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume17-
dc.identifier.doi10.3348/kjr.2016.17.3.330-
dc.relation.page330-338-
dc.relation.journalKOREAN JOURNAL OF RADIOLOGY-
dc.contributor.googleauthorPark, Eun-Ah-
dc.contributor.googleauthorLee, Whal-
dc.contributor.googleauthorKang, Doo Kyoung-
dc.contributor.googleauthorKim, Sung Jin-
dc.contributor.googleauthorKim, Young-Ju-
dc.contributor.googleauthorKim, Yookyung-
dc.contributor.googleauthorSung, Yon Mi-
dc.contributor.googleauthorSong, Soon-Young-
dc.contributor.googleauthorOh, Yu-Whan-
dc.contributor.googleauthorYong, Hwan Seok-
dc.relation.code2016010597-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsongsy-


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