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dc.contributor.author공구-
dc.date.accessioned2018-05-23T02:30:15Z-
dc.date.available2018-05-23T02:30:15Z-
dc.date.issued2016-05-
dc.identifier.citationNATURE COMMUNICATIONS, v. 7, Page. 1-11en_US
dc.identifier.issn2041-1723-
dc.identifier.urihttps://www.nature.com/articles/ncomms11383-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/71467-
dc.description.abstractSomatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutational signature on the genome. Using somatic mutation catalogues from 560 breast cancer whole-genome sequences, here we show that each of 12 base substitution, 2 insertion/deletion (indel) and 6 rearrangement mutational signatures present in breast tissue, exhibit distinct relationships with genomic features relating to transcription, DNA replication and chromatin organization. This signature-based approach permits visualization of the genomic distribution of mutational processes associated with APOBEC enzymes, mismatch repair deficiency and homologous recombinational repair deficiency, as well as mutational processes of unknown aetiology. Furthermore, it highlights mechanistic insights including a putative replication-dependent mechanism of APOBEC-related mutagenesis.en_US
dc.description.sponsorshipThis analysis has been performed on data from a project funded through the ICGC Breast Cancer Working group by the Breast Cancer Somatic Genetics Study (a European research project funded by the European Community's Seventh Framework Programme (FP7/2010-2014) under the grant agreement number 242006); the Triple Negative project funded by the Wellcome Trust (grant reference 077012/Z/05/Z) and the HER2+ project funded by Institut National du Cancer (INCa) in France (Grants No. 226-2009, 02-2011, 41-2012, 144-2008, 06-2012). The ICGC Asian Breast Cancer Project was funded through a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A111218-SC01). We would like to acknowledge the Wellcome Trust Sanger Institute Sequencing Core Facility, Core IT Facility and Cancer Genome Project Core IT team and Cancer Genome Project Core Laboratory team for general support. This research also used resources provided by the Los Alamos National Laboratory Institutional Computing Program, which is supported by the US Department of Energy National Nuclear Security Administration under Contract No. DE-AC52-06NA25396. Research performed at Los Alamos National Laboratory was carried out under the auspices of the National Nuclear Security Administration of the United States Department of Energy. S.M. is funded through the Breast Cancer Somatic Genetic Study (BASIS). L.B.A. is supported through a J. Robert Oppenheimer Fellowship at Los Alamos National Laboratory. D.G. is supported by the EU-FP7-SUPPRESSTEM project. A.L.R. is partially supported by the Dana-Farber/Harvard Cancer Center SPORE in Breast Cancer (NIH/NCI 5 P50 CA168504-02). M.S. was supported by the EU-FP7-DDR response project. C.S. is funded by FNRS (Fonds National de la Recherche Scientifique). G.K. is supported by National Research Foundation of Korea (NRF) grants NRF 2015R1A2A1A10052578. E.B. is funded by EMBL. SN-Z is a Wellcome Beit Fellow and personally funded by a Wellcome Trust Intermediate Fellowship (WT100183MA). S.N.-Z. and X.Z. also work under the auspices of the COMSIG Consortium, supported by a Wellcome Trust Strategic Award (101126/B/13/Z). We would like to acknowledge all members of the ICGC Breast Cancer Working Group, ICGC Asian Breast Cancer Project, and Oslo Breast Cancer Consortium (OSBREAC).en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectMISMATCH REPAIRen_US
dc.subjectHOMOLOGOUS-RECOMBINATIONen_US
dc.subjectCHROMATIN ORGANIZATIONen_US
dc.subjectFISSION YEASTen_US
dc.subjectABASIC SITEen_US
dc.subjectMATING-TYPEen_US
dc.subjectDNA-REPAIRen_US
dc.subjectREPLICATIONen_US
dc.subjectSIGNATURESen_US
dc.subjectSPECIFICITYen_US
dc.titleThe topography of mutational processes in breast cancer genomesen_US
dc.typeArticleen_US
dc.relation.no11383-
dc.relation.volume7-
dc.identifier.doi10.1038/ncomms11383-
dc.relation.page1-11-
dc.relation.journalNATURE COMMUNICATIONS-
dc.contributor.googleauthorMorganella, Sandro-
dc.contributor.googleauthorAlexandrov, Ludmil B.-
dc.contributor.googleauthorGlodzik, Dominik-
dc.contributor.googleauthorZou, Xueqing-
dc.contributor.googleauthorDavies, Helen-
dc.contributor.googleauthorStaaf, Johan-
dc.contributor.googleauthorSieuwerts, Anieta M.-
dc.contributor.googleauthorBrinkman, Arie B.-
dc.contributor.googleauthorMartin, Sancha-
dc.contributor.googleauthorKong, Gu-
dc.relation.code2016003600-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidgkong-


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