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dc.contributor.author최한곤-
dc.date.accessioned2018-05-03T05:15:07Z-
dc.date.available2018-05-03T05:15:07Z-
dc.date.issued2016-11-
dc.identifier.citationDRUG DELIVERY, v. 23, No. 8, Page. 2806-2812en_US
dc.identifier.issn1071-7544-
dc.identifier.issn1521-0464-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.3109/10717544.2015.1089958-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/71289-
dc.description.abstractTo develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD. However, PVP did the opposite. In particular, the neomycin sulfate-loaded HD composed of drug, PVA, PVP and SA at the weight ratio of 1/10/0.8/0.8 had excellent swelling and bioadhesive capacity, good elasticity and fast drug release. Moreover, this HD gave more improved wound curing effect compared to the commercial product, ensured the disappearance of granulation tissue and recovered the wound tissue to normal. Therefore, this novel neomycin sulfate-loaded HD could be an effective pharmaceutical product for the treatment of wounds.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of South Korea (NRF) grant funded by the South Korea government (MEST) ( No. 2015R1A2A2A05027872). The authors report that there are no conflicts of interest.en_US
dc.language.isoen_USen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.subjectHistological examinationen_US
dc.subjecthydrogel dressingen_US
dc.subjectneomycin sulfateen_US
dc.subjectpolyvinyl alcoholen_US
dc.subjectpolyvinyl pyrrolidoneen_US
dc.subjectsodium alginateen_US
dc.subjectwound-curing effecten_US
dc.subjectIN-VIVO EVALUATIONen_US
dc.subjectPOLYVINYL-ALCOHOLen_US
dc.subjectSODIUM ALGINATEen_US
dc.subjectGEL CHARACTERIZATIONen_US
dc.subjectHEALING EVALUATIONen_US
dc.subjectDRUG-DELIVERYen_US
dc.subjectCHITOSANen_US
dc.subjectGELATINen_US
dc.subjectCARBOXYMETHYLCELLULOSEen_US
dc.subjectNANOFIBERSen_US
dc.titleNovel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effecten_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume23-
dc.identifier.doi10.3109/10717544.2015.1089958-
dc.relation.page2806-2812-
dc.relation.journalDRUG DELIVERY-
dc.contributor.googleauthorChoi, JS-
dc.contributor.googleauthorKim, DW-
dc.contributor.googleauthorKim, DS-
dc.contributor.googleauthorKim, JO-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorCho, KH-
dc.contributor.googleauthorYoun, YS-
dc.contributor.googleauthorJin, SG-
dc.contributor.googleauthorChoi, HG-
dc.relation.code2016005084-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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