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Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect

Title
Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect
Author
최한곤
Keywords
Histological examination; hydrogel dressing; neomycin sulfate; polyvinyl alcohol; polyvinyl pyrrolidone; sodium alginate; wound-curing effect; IN-VIVO EVALUATION; POLYVINYL-ALCOHOL; SODIUM ALGINATE; GEL CHARACTERIZATION; HEALING EVALUATION; DRUG-DELIVERY; CHITOSAN; GELATIN; CARBOXYMETHYLCELLULOSE; NANOFIBERS
Issue Date
2016-11
Publisher
TAYLOR & FRANCIS LTD
Citation
DRUG DELIVERY, v. 23, No. 8, Page. 2806-2812
Abstract
To develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD. However, PVP did the opposite. In particular, the neomycin sulfate-loaded HD composed of drug, PVA, PVP and SA at the weight ratio of 1/10/0.8/0.8 had excellent swelling and bioadhesive capacity, good elasticity and fast drug release. Moreover, this HD gave more improved wound curing effect compared to the commercial product, ensured the disappearance of granulation tissue and recovered the wound tissue to normal. Therefore, this novel neomycin sulfate-loaded HD could be an effective pharmaceutical product for the treatment of wounds.
URI
https://www.tandfonline.com/doi/abs/10.3109/10717544.2015.1089958https://repository.hanyang.ac.kr/handle/20.500.11754/71289
ISSN
1071-7544; 1521-0464
DOI
10.3109/10717544.2015.1089958
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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