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Characterization of in vitro metabolites of methylenedioxypyrovalerone (MDPV): An N-oxide metabolite formation mediated by flavin monooxygenase

Title
Characterization of in vitro metabolites of methylenedioxypyrovalerone (MDPV): An N-oxide metabolite formation mediated by flavin monooxygenase
Author
유혜현
Keywords
Methylenedioxypyrovalerone; Metabolite; N-oxide; FMO; Human liver microsomes; RESOLUTION MASS-SPECTROMETRY; 3,4-METHYLENEDIOXYPYROVALERONE MDPV; BATH SALTS; DRUG-METABOLISM; PHARMACOLOGY; TRANSPORTER; CATHINONES; TOXICOLOGY; CHEMISTRY; URINE
Issue Date
2016-11
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v. 131, Page. 160-166
Abstract
Methylenedioxypyrovalerone (MDPV) has emerged in recent years as a-recreational substance with psychostimulant properties. In this study, in vitro metabolites of MDPV were characterized based on liquid chromatography/quadrupole-time-of-flight mass spectrometry(LC/QTOF MS). MDPV was incubated with human liver microsomes, human recombinant cDNA-expressed cytochrome P450 enzymes and flavin monooxygenase (FMO). MDPV was metabolized to yield eight metabolites (M1-M8)with major metabolic reactions such as demethylenation and oxidation. Among them, M6 was assigned as an N-oxide metabolite. FMO was found to be a principal enzyme responsible for the formation of M6; FMO1 and FMO3 were the main enzymes involved in N-oxidation of MDPV. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0731708516304708https://repository.hanyang.ac.kr/handle/20.500.11754/71286
ISSN
0731-7085; 1873-264X
DOI
10.1016/j.jpba.2016.08.025
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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