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dc.contributor.author유혜현-
dc.date.accessioned2018-04-24T05:52:24Z-
dc.date.available2018-04-24T05:52:24Z-
dc.date.issued2016-10-
dc.identifier.citationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1033, Page. 296-300en_US
dc.identifier.issn1570-0232-
dc.identifier.issn1873-376X-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1570023216307280-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/70365-
dc.description.abstract5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB) is a designer drug of phenethylamine and amphetamine class. In this study, the in vitro metabolism of 5-APDB was investigated in rat and human liver microsomes and human hepatocytes to characterize its metabolites. 5-APDB was incubated with microsomes or hepatocytes, and the reaction mixture was analyzed using liquid chromatography-quadrupole time-of-flight with tandem mass spectrometry (LC-QJTOF-MS). 5-APDB was metabolized to yield three metabolites (M1, M2 and M3). These metabolites were structurally characterized on the basis of accurate mass analysis and MS/MS fragmentation patterns. Metabolite M1 and M2 were identified as hydroxylated metabolites in the benzofuran moiety; M3 was a reduced metabolite which may be generated from M1 or M2 via dehydration. These results provide evidence for the in vivo 5-APDB metabolism, and would be forensically useful for the detection of 5-APDB and its metabolites in biological samples. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by a Grant from the National Forensic Service (2015-Forensic Toxicology-05)en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subject5-APDBen_US
dc.subjectDesigner drugen_US
dc.subjectMetaboliteen_US
dc.subjectLC-Q/TOP-MSen_US
dc.subjectHUMAN LIVER-MICROSOMESen_US
dc.subject5-(2-AMINOPROPYL)BENZOFURAN 5-APBen_US
dc.subjectILLEGAL PRODUCTSen_US
dc.subjectDESIGNER DRUGSen_US
dc.subjectGC-MSen_US
dc.subjectINTOXICATIONen_US
dc.subjectANALOGSen_US
dc.subjectURINEen_US
dc.subjectRATen_US
dc.titleTentative identification of in vitro metabolites of 5-APDB, a synthetic benzofuran, by LC-Q/TOF-MSen_US
dc.typeArticleen_US
dc.relation.volume1033-
dc.identifier.doi10.1016/j.jchromb.2016.08.043-
dc.relation.page296-300-
dc.relation.journalJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES-
dc.contributor.googleauthorPark, JS-
dc.contributor.googleauthorRehman, SU-
dc.contributor.googleauthorKim, IS-
dc.contributor.googleauthorChoi, MS-
dc.contributor.googleauthorLee, JS-
dc.contributor.googleauthorIn, S-
dc.contributor.googleauthorYoo, HH-
dc.relation.code2016001027-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidyoohh-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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