Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-04-24T05:52:24Z | - |
dc.date.available | 2018-04-24T05:52:24Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1033, Page. 296-300 | en_US |
dc.identifier.issn | 1570-0232 | - |
dc.identifier.issn | 1873-376X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1570023216307280 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/70365 | - |
dc.description.abstract | 5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB) is a designer drug of phenethylamine and amphetamine class. In this study, the in vitro metabolism of 5-APDB was investigated in rat and human liver microsomes and human hepatocytes to characterize its metabolites. 5-APDB was incubated with microsomes or hepatocytes, and the reaction mixture was analyzed using liquid chromatography-quadrupole time-of-flight with tandem mass spectrometry (LC-QJTOF-MS). 5-APDB was metabolized to yield three metabolites (M1, M2 and M3). These metabolites were structurally characterized on the basis of accurate mass analysis and MS/MS fragmentation patterns. Metabolite M1 and M2 were identified as hydroxylated metabolites in the benzofuran moiety; M3 was a reduced metabolite which may be generated from M1 or M2 via dehydration. These results provide evidence for the in vivo 5-APDB metabolism, and would be forensically useful for the detection of 5-APDB and its metabolites in biological samples. (C) 2016 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a Grant from the National Forensic Service (2015-Forensic Toxicology-05) | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | 5-APDB | en_US |
dc.subject | Designer drug | en_US |
dc.subject | Metabolite | en_US |
dc.subject | LC-Q/TOP-MS | en_US |
dc.subject | HUMAN LIVER-MICROSOMES | en_US |
dc.subject | 5-(2-AMINOPROPYL)BENZOFURAN 5-APB | en_US |
dc.subject | ILLEGAL PRODUCTS | en_US |
dc.subject | DESIGNER DRUGS | en_US |
dc.subject | GC-MS | en_US |
dc.subject | INTOXICATION | en_US |
dc.subject | ANALOGS | en_US |
dc.subject | URINE | en_US |
dc.subject | RAT | en_US |
dc.title | Tentative identification of in vitro metabolites of 5-APDB, a synthetic benzofuran, by LC-Q/TOF-MS | en_US |
dc.type | Article | en_US |
dc.relation.volume | 1033 | - |
dc.identifier.doi | 10.1016/j.jchromb.2016.08.043 | - |
dc.relation.page | 296-300 | - |
dc.relation.journal | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | - |
dc.contributor.googleauthor | Park, JS | - |
dc.contributor.googleauthor | Rehman, SU | - |
dc.contributor.googleauthor | Kim, IS | - |
dc.contributor.googleauthor | Choi, MS | - |
dc.contributor.googleauthor | Lee, JS | - |
dc.contributor.googleauthor | In, S | - |
dc.contributor.googleauthor | Yoo, HH | - |
dc.relation.code | 2016001027 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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