Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민형 | - |
dc.date.accessioned | 2018-04-19T07:58:11Z | - |
dc.date.available | 2018-04-19T07:58:11Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | Tissue Engineering C, 2012, 18(4), P.245-251 | en_US |
dc.identifier.issn | 1937-3384 | - |
dc.identifier.issn | 1937-3392 | - |
dc.identifier.uri | https://www.liebertpub.com/doi/abs/10.1089/ten.tec.2011.0373 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/69498 | - |
dc.description.abstract | For bone regeneration applications, scaffolds made from a composite of a biodegradable polymer and ceramic have advantages over scaffolds made from only one component (biodegradable polymer or ceramic alone). In this study, a simple and rapid method was developed to induce hydroxyapatite (HA) nanoparticle adsorption on polyglycolic acid (PGA) scaffold surfaces. PGA meshes were coated with HA nanoparticles by immersing the scaffolds in a buffer solution containing 3,4-dihydroxyphenylalanine (DOPA), a critical, functional element in mussel adhesive protein known to strongly bind to various materials. Substantial HA coating on PGA scaffolds was achieved within 24 hours of immersion, as determined according to selective staining of ceramic particles, scanning electron microscopy, X-ray photoelectron spectroscopy, and energy-dispersive spectroscopy. To evaluate the osteoconduction efficacy of the scaffolds in vivo, PGA scaffolds, DOPA-coated PGA scaffolds, PGA scaffolds immersed in HA solution, and HA- and DOPA-coated PGA (HA-DOPA-PGA) scaffolds were implanted in critical-sized defects in mouse skulls for 8 weeks. Micro-computed tomography and histological analyses showed that bone regeneration in vivo was far more extensive on HA-DOPA-PGA scaffolds than on the other scaffolds. DOPA offers an efficient and simple method of HA coating on polymer scaffolds. HA- polymer composite scaffolds fabricated using this method could be useful as bone graft. | en_US |
dc.description.sponsorship | This study was supported by grants from the National Research Foundation of Korea (2009-0080769) and the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A101539). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Mary Ann Leibert INC | en_US |
dc.subject | BONELIKE APATITE GROWTH | en_US |
dc.subject | COMPOSITE SCAFFOLDS | en_US |
dc.subject | IN-VITRO | en_US |
dc.subject | TISSUE | en_US |
dc.subject | MICROSPHERES | en_US |
dc.subject | BIOMATERIALS | en_US |
dc.subject | REPLACEMENT | en_US |
dc.subject | MEMBRANES | en_US |
dc.subject | ADHESION | en_US |
dc.subject | BEHAVIOR | en_US |
dc.title | 3,4-Dihydroxyphenylalanine-Assisted Hydroxyapatite Nanoparticle Coating on Polymer Scaffolds for Efficient Osteoconduction | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1089/ten.tec.2011.0373 | - |
dc.relation.page | 245-251 | - |
dc.relation.journal | TISSUE ENGINEERING PART C-METHODS | - |
dc.contributor.googleauthor | Kim, Byung-Soo | - |
dc.contributor.googleauthor | Yang, Hee Seok | - |
dc.contributor.googleauthor | Park, Jooyeon | - |
dc.contributor.googleauthor | La, Wan Geun | - |
dc.contributor.googleauthor | Kim, Byung-Soo | - |
dc.contributor.googleauthor | Jang, Hyeon-ki | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.relation.code | 2012216619 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | minhyung | - |
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