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dc.contributor.author심지원-
dc.date.accessioned2018-04-19T07:27:08Z-
dc.date.available2018-04-19T07:27:08Z-
dc.date.issued2012-03-
dc.identifier.citationNature Cell Biology, 2012, 14(4), P.394-400en_US
dc.identifier.issn1465-7392-
dc.identifier.urihttps://www.nature.com/articles/ncb2453-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/69470-
dc.description.abstractThe Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell-plasmatocytes, crystal cells and lamellocytes-the functions of which are reminiscent of mammalian myeloid cells'. During the first and early second instars of larval development, the lymph gland contains only progenitors, whereas in the third instar, a medial region of the primary lobe of the lymph gland called the medullary zone contains these progenitors(2), and maturing blood cells are found juxtaposed in a peripheral region designated the cortical zone(2). A third group of cells referred to as the posterior signalling centre functions as a haematopoietic niche(3,4). Similarly to mammalian myeloid cells, Drosophila blood cells respond to multiple stresses including hypoxia, infection and oxidative stress(5-7). However, how systemic signals are sensed by myeloid progenitors to regulate cell-fate determination has not been well described. Here, we show that the haematopoietic progenitors of Drosophila are direct targets of systemic (insulin) and nutritional (essential amino acid) signals, and that these systemic signals maintain the progenitors by promoting Wingless (WNT in mammals) signalling. We expect that this study will promote investigation of such possible direct signal sensing mechanisms by mammalian myeloid progenitors.en_US
dc.description.sponsorshipWe thank C. J. Evans, K. T. Jones, other members of the Banerjee laboratory and J. A. Martinez-Agosto for helpful comments and discussions. We thank R. Erdmann for help with the amino-acid supplementation assay and S. Pham for confirming experiments with anti-Hml in different genetic backgrounds. We acknowledge P. Leopold, E. Hafen, E. Rulifs on, L. Pick, T. P. Neufeld, R. A. Schulz, A. Courey, J-M. Reichhart, the VDRC Stock Center and the Bloomington Stock Center for fly stocks, the Developmental Studies Hybridoma Bank (University of Iowa), the Drosophila Genomics Resource Center and J. Fessler for reagents. We also thank M. Cr ozatiers' group for providing the in situ hybridization protocol. This work was supported by an NIH grant (5R01 HL067395) to U.B. and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Training Grant at UCLA to J.S.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectNSULIN-LIKE PEPTIDESen_US
dc.subjectHOST-DEFENSEen_US
dc.subjectBLOOD-CELLSen_US
dc.subjectSTEM-CELLSen_US
dc.subjectGROWTHen_US
dc.subjectACTIVATIONen_US
dc.subjectPROTEINen_US
dc.subjectMELANOGASTERen_US
dc.subjectINFLAMMATIONen_US
dc.subjectMAINTENANCEen_US
dc.titleDirect sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophilaen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume14-
dc.identifier.doi10.1038/ncb2453-
dc.relation.page394-394-
dc.relation.journalNATURE CELL BIOLOGY-
dc.contributor.googleauthorShim, J.-
dc.contributor.googleauthorMukherjee, T.-
dc.contributor.googleauthorBanerjee, U.-
dc.relation.code2012206935-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjshim-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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