Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2018-04-19T01:43:28Z | - |
dc.date.available | 2018-04-19T01:43:28Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v. 307, Page. 62-71 | en_US |
dc.identifier.issn | 0041-008X | - |
dc.identifier.issn | 1096-0333 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0041008X16301971 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/69318 | - |
dc.description.abstract | Impaired immune responses in skin play a pivotal role in the development and progression of chemical-associated inflammatory skin disorders. In this study, we synthesized new flavonoid derivatives from macakurzin C, and identified in vitro and in vivo efficacy of a potent anti-inflammatory flavonoid, Compound 14 (CPD 14), with its underlying mechanisms. In lipopolysaccharide (LPS)-stimulated murine macrophages and IFN-gamma/TNF-alpha-stimulated human keratinocytes, CPD 14 significantly inhibited the release of inflammatory mediators including nitric oxide (NO), prostaglandins, and cytokines (IC50 for NO inhibition in macrophages: 4.61 mu M). Attenuated NF-kappa B signaling and activated Nrf2/HO-1 pathway were responsible for the anti-inflammatory effects of CPD 14. The in vivo relevance was examined in phorbol 12-myristate 13-acetate (TPA)-induced acute skin inflammation and oxazolone-induced atopic dermatitis models. Topically applied CPD 14 significantly protected both irritation- and sensitization-associated skin inflammation by suppressing the expression of inflammatory mediators. In summary, we demonstrated that a newly synthesized flavonoid, CPD 14, has potent inhibitory effects on skin inflammation, suggesting it is a potential therapeutic candidate to treat skin disorders associated with excessive inflammation. (C) 2016 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a grant from the Ministry of Health and Welfare of Korea (HI14C2284) and grants from the Basic Science Research Program through the National Research Foundation of Korea supported by the Ministry of Science, ICT & Future Planning (NRF-2014R1A1A2056603) and by the Ministry of Education (NRF-2014R1A1A2058459). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Synthetic flavonoid | en_US |
dc.subject | Anti-inflammatory activity | en_US |
dc.subject | TPA-induced acute inflammation | en_US |
dc.subject | Oxazolone-induced atopic dermatitis | en_US |
dc.subject | NF-KAPPA-B | en_US |
dc.subject | TRANSCRIPTION FACTORS NRF2 | en_US |
dc.subject | ATOPIC-DERMATITIS | en_US |
dc.subject | TNF-ALPHA | en_US |
dc.subject | ANTIINFLAMMATORY ACTIVITY | en_US |
dc.subject | BIOLOGICAL EVALUATION | en_US |
dc.subject | CONTACT-DERMATITIS | en_US |
dc.subject | INDUCED EXPRESSION | en_US |
dc.subject | HEME OXYGENASE | en_US |
dc.subject | ACTIVATION | en_US |
dc.title | A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target | en_US |
dc.type | Article | en_US |
dc.relation.volume | 307 | - |
dc.identifier.doi | 10.1016/j.taap.2016.07.013 | - |
dc.relation.page | 62-71 | - |
dc.relation.journal | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.contributor.googleauthor | Akram, M | - |
dc.contributor.googleauthor | Shin, I | - |
dc.contributor.googleauthor | Kim, KA | - |
dc.contributor.googleauthor | Noh, D | - |
dc.contributor.googleauthor | Baek, S.H | - |
dc.contributor.googleauthor | Chang, SY | - |
dc.contributor.googleauthor | Kim, H | - |
dc.contributor.googleauthor | Bae, ON | - |
dc.relation.code | 2016001754 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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