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A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association

Title
A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association
Author
최한곤
Keywords
Albumin nanoparticles; Supramolecular association; beta-cyclodextrin; Adamantane; Self-assembly; Tumor targeting; DRUG-DELIVERY; CANCER-THERAPY; CHITOSAN NANOPARTICLES; GUEST INTERACTIONS; SYSTEMS; THERAPEUTICS; CHALLENGES; DESIGN; DRIVEN
Issue Date
2016-08
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 147, Page. 281-290
Abstract
Albumin has been viewed as one of the most attractive biomacromolecules for making nanoparticulate systems due to its biocompatibility and chemical functionality. Thus far, albumin nanoparticles (NPs) are prepared by several limited methods, such as, desolvation, emulsification or high-pressure homogenization. In this article, we introduce a new albumin NPs prototype fabricated via a 'host' ((3-cyclodextrin)-'guest' (adamantane) supramolecular association. These NPs (GC-CD/HSA-ADA NPs) consisted of13-cyclodextrin-modified glycol chitosan (GC-CD) and adamantane-conjugated human serum albumin (HSA-ADA) (GC-CD/HSA-ADA NPs) that were facilely prepared by a consequent dropwise mixing and sonication method. Doxorubicin-loaded GC-CD/HSA-ADA NPs exhibited an appropriate particle size (similar to 260 nm), good physicochemical stability (similar to 48 h), significant HCT116 cell cytotoxicity (IC50: 0.32 mu g/ml) and cell internalization. Furthermore, GC-CD/HSA-ADA NPs showed excellent tumor targetability probably due to gp60-mediated transcytosis mechanism because it was markedly accumulated in the tumor site of a HCT 116 cell-xenograft mouse. Based on these results, these albumin NPs will be promising for a new NP platform that can be applied for cancer therapy or imaging. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0927776516305860http://hdl.handle.net/20.500.11754/68033
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2016.08.009
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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