Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채영규 | - |
dc.date.accessioned | 2018-04-16T05:52:01Z | - |
dc.date.available | 2018-04-16T05:52:01Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Biochip journal, 2012, 6(2), P.165-173 | en_US |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs13206-012-6209-1 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67994 | - |
dc.description.abstract | Neuroinflammation can contribute to neuronal dysfunction, death and several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. Lipopolysaccharide (LPS)-induced neuroinflammation severely affects neurons and can contribute to neuronal dysfunction and degeneration by causing the release of inflammatory and neurotoxic factors. We evaluated the long-term effects of treating differentiated SH-SY5Y cells with LPS to mimic LPS-induced neuroinflammation. Using matrix assisted laser desorption ionization-time of flight mass spectrometry and MetaCore pathway analysis software (GeneGo), the proteomic expression profiles of differentiated SH-SY 5Y cells after LPS treatment was studied to determine the inflammatory effects on the process of SH-SY5Y differentiation. Long-term LPS treatment resulted in the upregulation of phosphodiesterase 4B (PDE4B), slit robo GTPase (SRGAP2), transcription repressor E2F-6, vimentin, and 70 kDa heat shock protein 9 (Mortalin/HSPA9). Taken together, our results suggest that LPS-treated differentiation of SH-SY5Y cells can lend insight into the multiple pathways involved in neurological diseases. | en_US |
dc.description.sponsorship | This work was supported by a grant of the Korean Health Technology R&D Project (A101712), Ministry for Health, Welfare & Family Affairs, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Biochip Society | en_US |
dc.subject | SH-SY5Y cells | en_US |
dc.subject | Lipopolysaccharide | en_US |
dc.subject | MetaCore pathway analysis software (GeneGo) | en_US |
dc.subject | Neuroinflammation | en_US |
dc.title | Lipopolysaccharide-mediated protein expression profiling on neuronal differentiated SH-SY5Y cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.1007/s13206-012-6209-1 | - |
dc.relation.page | 165-173 | - |
dc.relation.journal | BIOCHIP JOURNAL | - |
dc.contributor.googleauthor | Das, N. D. | - |
dc.contributor.googleauthor | Choi, M. R. | - |
dc.contributor.googleauthor | Jung, K. H. | - |
dc.contributor.googleauthor | Park, J. H. | - |
dc.contributor.googleauthor | Lee, H. T. | - |
dc.contributor.googleauthor | Kim, S. H. | - |
dc.contributor.googleauthor | Chai, Y. G. | - |
dc.relation.code | 2012217720 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | ygchai | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.