Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박찬금 | - |
dc.date.accessioned | 2018-04-16T05:42:49Z | - |
dc.date.available | 2018-04-16T05:42:49Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Journal of Cutaneous Pathology, 2012, 39(6), P.582-595 | en_US |
dc.identifier.issn | 0303-6987 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0560.2012.01903.x | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67977 | - |
dc.description.abstract | The non-specific clinical findings and variable histopathological features of cutaneous tuberculosis and non-tuberculous mycobacterial infections often make it difficult to establish a diagnosis and initiate appropriate therapy. We investigated 25 patients diagnosed with mycobacterial infections of the skin in Hanyang University Hospital between 2001 and 2011. Skin biopsy specimens were re-evaluated by various histopathological criteria and molecular studies. To identify the mycobacteria, we performed staining for acid-fast bacilli and also completed polymerase chain reaction analysis. The non-tuberculous mycobacterium species were identified by genetic sequencing of formalin-fixed, paraffin-embedded tissues. Immunocompromised status was more frequent in non-tuberculous mycobacterial infections than in tuberculosis (p = 0.017) while disease duration was longer in tuberculosis (p = 0.026). Microscopically, neutrophil infiltration, interstitial granuloma, small vessel proliferation and increased numbers of bacilli were found to be associated with non-tuberculous mycobacterial infections (all p < 0.05). In contrast, giant cells, plasma cells, tuberculoid granulomas and necrosis were associated with tuberculosis (all p < 0.05). There were no species-specific histopathological findings in non-tuberculous mycobacterial infections. The significant histopathological differences between cutaneous tuberculous and non-tuberculous mycobacterial infections are helpful in considering differential diagnoses. In addition, molecular techniques together with clinico-pathological findings may assist in making accurate diagnoses of cutaneous non-tuberculous mycobacterial infections. Min K-W, Ko JY, Park CK. Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | infection | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | non-tuberculous mycobacterium | en_US |
dc.title | Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.1111/j.1600-0560.2012.01903.x | - |
dc.relation.page | 582-595 | - |
dc.relation.journal | JOURNAL OF CUTANEOUS PATHOLOGY | - |
dc.contributor.googleauthor | Min, K. W. | - |
dc.contributor.googleauthor | Ko, J. Y. | - |
dc.contributor.googleauthor | Park, C. K. | - |
dc.relation.code | 2012204948 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkcg | - |
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