Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최호진 | - |
dc.date.accessioned | 2018-04-16T05:17:07Z | - |
dc.date.available | 2018-04-16T05:17:07Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Immunopharmacology & Immunotoxicology, 2012, 34(3), P.398-407(10) | en_US |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/abs/10.3109/08923973.2011.611137?journalCode=iipi20 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67939 | - |
dc.description.abstract | This work aimed to assess anti-inflammatory and related properties of a phospholipid mixture purified from porcine lung tissues, named KT&G101, which is being developed as a novel topical remedy for atopic dermatitis. KT&G101 consists of pure phospholipids, mainly phosphatidylcholine (PC) and other phospholipids such as phosphatidylinositol (PI) and phosphatidylserine (PS). Its predominant PC species is 1,2-dipalmitoylphosphatidylcholine (DPPC). KT&G101 exhibited an anti-angiogenic activity in the chick chorioallantoic membrane (CAM) assay. Oral administration of KT&G101 at the dosages of 100, 200 and 400 mg/kg body weight gave rise to an inhibition of 15.4%, 25.3% and 30.1% in the vascular permeability assay, respectively. In the carrageenan-induced inflammation in the air pouches, KT&G101 significantly diminished the volume of exudates in the pouches, the number of polymorphonuclear leukocytes and nitrite content in exudates. In the acetic acid-induced writhing response, oral administration of KT&G101 at the dosages of 50, 100 and 200 mg/kg body weight showed the reduction of 21.6%, 51.6% and 60.8% in the pain response of mice, respectively. It was also able to diminish the nitric oxide (NO) and reactive oxygen species (ROS) levels in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. KT&G101 displayed a significant suppression on the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the stimulated RAW264.7 cells. However, the free radical scavenging activity of KT&G101 was detected to be very weak in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Taken together, KT&G101 possesses anti-inflammatory and related antinociceptive and anti-angiogenic activities, which indirectly supports its use as an anti-atopic therapy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.subject | anti-angiogenic | en_US |
dc.subject | anti-inflammatory | en_US |
dc.subject | antinociceptive | en_US |
dc.subject | cyclooxygenase-2 | en_US |
dc.subject | inducible nitric oxide synthase | en_US |
dc.subject | nitric oxide | en_US |
dc.subject | Phospholipid | en_US |
dc.subject | reactive oxygen species | en_US |
dc.title | Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3109/08923973.2011.611137 | - |
dc.relation.journal | IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | - |
dc.contributor.googleauthor | Jung, Hyun-Joo | - |
dc.contributor.googleauthor | Moon, Jeong-Su | - |
dc.contributor.googleauthor | Park, A Rum | - |
dc.contributor.googleauthor | Choi, Hojin | - |
dc.contributor.googleauthor | Lee, Jong Eun | - |
dc.contributor.googleauthor | Choi, Seong-Hyun | - |
dc.contributor.googleauthor | Lim, Chang-Jin | - |
dc.relation.code | 2012203942 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chj | - |
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