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Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia

Title
Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia
Author
최정혜
Keywords
Aplastic anemia; Allogeneic hematopoietic stem cell transplantation; Elderly
Issue Date
2012-10
Publisher
Elsevier Science B. V. Amsterdam
Citation
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, OCT 2012, 18(10), p1500-p1508, 9p.
Abstract
Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients ≤40 years old (younger patient group [YPG]). Age at allo-HSCT ≤40 years, time from diagnosis to allo-HSCT ≤6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival.
URI
https://www.sciencedirect.com/science/article/pii/S1083879112001383http://hdl.handle.net/20.500.11754/67704
ISSN
1083-8791
DOI
10.1016/j.bbmt.2012.03.015
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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