Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia
- Title
- Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia
- Author
- 최정혜
- Keywords
- Aplastic anemia; Allogeneic hematopoietic stem cell transplantation; Elderly
- Issue Date
- 2012-10
- Publisher
- Elsevier Science B. V. Amsterdam
- Citation
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, OCT 2012, 18(10), p1500-p1508, 9p.
- Abstract
- Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients ≤40 years old (younger patient group [YPG]). Age at allo-HSCT ≤40 years, time from diagnosis to allo-HSCT ≤6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival.
- URI
- https://www.sciencedirect.com/science/article/pii/S1083879112001383http://hdl.handle.net/20.500.11754/67704
- ISSN
- 1083-8791
- DOI
- 10.1016/j.bbmt.2012.03.015
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML