Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-04-16T02:41:37Z | - |
dc.date.available | 2018-04-16T02:41:37Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Arthritis and Rheumatism, 2012, 64(6), P.1960-1969 | en_US |
dc.identifier.issn | 2326-5205 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/art.34361 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67576 | - |
dc.description.abstract | Objective Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development. Methods Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based casecontrol association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Results Evidence of associations was detected in multiple SNPs. The best overall P values were obtained for SNPs rs5030437 and rs4755453 (P = 7.85 x 10(-5) and P = 4.73 x 10(-5), respectively) without significant heterogeneity among populations (P = 0.67 and P = 0.50, respectively, in Q statistic). In addition, SNP rs540386, which was previously reported to be associated with rheumatoid arthritis (RA), was found to be in linkage disequilibrium with these 2 SNPs (r2 = 0.95) and demonstrated evidence of association with SLE in the same direction (meta-analysis P = 9.15 x 10(-4), OR 0.89 [95% CI 0.830.95]). The presence of thrombocytopenia improved the overall results in different populations (meta-analysis P = 1.99 x 10(-6), OR 0.57 [95% CI 0.450.72], for rs5030470). Finally, evidence of family-based association in 34 African American pedigrees with the presence of thrombocytopenia was detected in 1 available SNP (rs5030437) with a Z score magnitude of 2.28 (P = 0.02) under a dominant model. Conclusion Our data indicate the presence of association of TRAF6 with SLE, consistent with the previous report of association with RA. These data provide further support for the involvement of TRAF6 in the pathogenesis of autoimmunity. | en_US |
dc.description.sponsorship | Supported by the NIH (grants R37-AI-024717, AI-063622, AI-071651, U19-AI-082714, P01-AI-083194, R01-AR-042460, AR-043274, AR-043814, AR-044804, P50-AR-048940, AR-052300, AR-053483, AR-058554, AR-060366, AR-42525, AR-43727, N01-AR-062277, CA-141700-01, GM-063483, HD-07463, K08-AI-083790, K24-AR-002138, M01-RR-00079, P01-AR-049084, P30-DK-42086, P60-AR-049459, P60-AR-053308, P60-2-AR-030692, R01-AR-33062, R21-AI-070304, P20-RR-015577, P20-RR-020143, RR-031152, UL1-RR-024999, UL1-RR-025005, UL1-RR-025741, UL1-RR-029882, and 5UL1-RR-025777), the US Department of Defense (grant PR094002), the Lupus Foundation of America, the Alliance for Lupus Research, the Kirkland Scholar Program, the US Department of Veterans Affairs, the Korean Healthcare Technology Research and Development Project (grant A080588), the Korea Research Program for New Drug Target Discovery (grant 20090083335), the National Research Foundation of Korea (grant 2010-0014162), the Lupus Research Institute (Novel Research grant), the Alliance for Lupus Research (Target Identification in Lupus grant), the Arthritis National Research Foundation (Eng Tan Scholar award), the European Science Foundation (within the framework of the Research Network Project BIOLUPUS, grant 07-RNP-083), the Swedish Research Council, the Swedish Association Against Rheumatism, the Swedish International Development Agency, King Gustaf V's 80th Jubilee Foundation, and the Federico Wilhelm Agricola Foundation (research grant). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | GENOME-WIDE ASSOCIATION | en_US |
dc.subject | AFRICAN-AMERICAN FAMILIES | en_US |
dc.subject | GENETIC ASSOCIATION | en_US |
dc.subject | ERYTHEMATOSUS | en_US |
dc.subject | SUSCEPTIBILITY | en_US |
dc.subject | VARIANTS | en_US |
dc.subject | LINKAGE | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.subject | PHENOTYPE | en_US |
dc.subject | 11P13 | en_US |
dc.title | Evaluation of TRAF6 in a large multiancestral lupus cohort | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 64 | - |
dc.identifier.doi | 10.1002/art.34361 | - |
dc.relation.page | 1960-1969 | - |
dc.relation.journal | ARTHRITIS AND RHEUMATISM | - |
dc.contributor.googleauthor | Namjou, B. | - |
dc.contributor.googleauthor | Choi, C. B. | - |
dc.contributor.googleauthor | Harley, I. T. | - |
dc.contributor.googleauthor | Alarcn-Riquelme, M. E. | - |
dc.contributor.googleauthor | Kelly, J. A. | - |
dc.contributor.googleauthor | Glenn, S. B. | - |
dc.contributor.googleauthor | Ojwang, J. O. | - |
dc.contributor.googleauthor | Adler, A. | - |
dc.contributor.googleauthor | Kim, K. | - |
dc.contributor.googleauthor | Gallant, C. J. | - |
dc.relation.code | 2012201020 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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