Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-04-16T02:40:39Z | - |
dc.date.available | 2018-04-16T02:40:39Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Genetic Testing and Molecular Biomarkers, 2012, 16(9), P.1105-1110 | en_US |
dc.identifier.issn | 1945-0265 | - |
dc.identifier.uri | https://www.liebertpub.com/doi/abs/10.1089/gtmb.2012.0096 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67574 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the tumor necrosis factor-alpha-inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. Methods: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and SLE susceptibility, using fixed and random effects models. Results: A total of eight comparative studies were included in this meta-analysis, which included four Asian, three European, and one African American population. Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p < 1.0 x 10(-9)). After stratification by ethnicity, the minor allele of rs2230926 was found to be significantly associated with SLE in Asians and Europeans (OR 1.821, 95% CI 1.495-2.219, p < 1.0 x 10(-9); OR 2.251, 95% CI 1.830-2.768, p < 1.0 x 10(-9)). In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p = 0.001; OR 2.145, 95% CI 1.731-2.658, p < 1.0 x 10(-9)). Furthermore, an association was found between the minor allele of rs3757173 and SLE in all study subjects (OR 1.540, 95% CI 1.017-2.331, p = 0.041). However, no association was found between SLE susceptibility and rs6922466 (OR 0.953, 95% CI 0.812-1.120, p = 0.561). Conclusions: This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with SLE susceptibility in different ethnic groups, namely in Asians and Europeans. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Mary Ann Liebert INC | en_US |
dc.subject | RHEUMATOID-ARTHRITIS | en_US |
dc.subject | JAPANESE POPULATION | en_US |
dc.subject | SUSCEPTIBILITY LOCI | en_US |
dc.subject | NEPHRITIS | en_US |
dc.subject | RESPONSES | en_US |
dc.subject | RISK | en_US |
dc.subject | A20 | en_US |
dc.title | Associations Between TNFAIP3 Gene Polymorphisms and Systemic Lupus Erythematosus: A Meta-Analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.1089/gtmb.2012.0096 | - |
dc.relation.page | 1105-1110 | - |
dc.relation.journal | INFLAMMATION RESEARCH | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Song, Gwan Gyu | - |
dc.relation.code | 2012204016 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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