Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진웅 | - |
dc.date.accessioned | 2018-04-16T02:25:51Z | - |
dc.date.available | 2018-04-16T02:25:51Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Colloids and Surfaces B-Biointerfaces, 2012, 94, P.51-57 | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776512000410?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67515 | - |
dc.description.abstract | Tocopheryl acetate is used as the oil component of nanoemulsions using a mixture of unsaturated phospholipids and polyethylene oxide-block-poly(epsilon-caprolactone) (PEO-b-PCL). This study investigates the effects of the lipid-polymer composition on the size and surface charge of nanoemulsions, microviscosity of the interfacial layer, and skin absorption of tocopheryl acetate. The lipid-polymer hybrid system exhibits excellent colloidal dispersion stability, which is comparable to that of polymer-based nanoemulsions. If lipids are used as emulsifiers, nanoemulsions show poor dispersion stability despite a good skin absorption enhancing effect. The amount of tocopheryl acetate absorbed by the skin increases with an increased lipid-to-polymer ratio, as determined using the hairless guinea pig skin loaded in a Franz-type diffusion cell. An 8:2 (w/w) mixture of unsaturated phospholipids and PEO-b-PCL exhibits the most efficient delivery of tocopheryl acetate into the skin. Our results show that tocopheryl acetate is absorbed almost twice as fast by the lipid-polymer hybrid system than the nanoemulsions stabilized with PEO-b-PCL. This study suggests that the lipid-polymer hybrid system can be used as an effective means of optimizing nanoemulsions in terms of dispersion stability and skin delivery capability. (C) 2012 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | We thank Dr. Young-Jin Lee and Dr. Seung Jae Baik for helpful discussion. This work was supported by the research fund of Hanyang University (HY-2011-N) and Amore Pacific Corporation (Seoul, Republic of Korea). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V | en_US |
dc.subject | Nanoemulsions | en_US |
dc.subject | Biodegradable polymers | en_US |
dc.subject | Polymeric emulsifiers | en_US |
dc.subject | Phospholipids | en_US |
dc.subject | Skin drug delivery | en_US |
dc.title | Tocopheryl acetate nanoemulsions stabilized with lipid-polymer hybrid emulsifiers for effective skin delivery | en_US |
dc.type | Article | en_US |
dc.relation.volume | 94 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2012.01.016 | - |
dc.relation.page | 51-57 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Nam, Y. S. | - |
dc.contributor.googleauthor | Kim, J. W. | - |
dc.contributor.googleauthor | Park, J. | - |
dc.contributor.googleauthor | Shim, J. | - |
dc.contributor.googleauthor | Lee, J. S. | - |
dc.contributor.googleauthor | Han, S. H. | - |
dc.relation.code | 2012212663 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | kjwoong | - |
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