Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-04-16T01:54:27Z | - |
dc.date.available | 2018-04-16T01:54:27Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | Arthritis Care & Research, Vol.64, No.1 [2011], p132-137 | en_US |
dc.identifier.issn | 2151-464X | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.20648 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67380 | - |
dc.description.abstract | ObjectiveWe describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort.MethodsThe Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI‐2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti‐DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated‐measures general linear models were used to evaluate SLEDAI‐2K and SDI over time between whites and nonwhites.ResultsOf the 298 patients, 87% were women, 55% were white, 12% were African American, 14% were Asian, 16% were Hispanic, and 2% were categorized as “other.” At enrollment, the mean age was 35.3 years, the mean SLEDAI‐2K score was 5.9, and the mean disease duration was 5.5 months. Mean SLEDAI‐2K scores decreased in the first year and then remained low. SLEDAI‐2K scores were significantly lower at each year in whites compared to nonwhites. Mean SDI scores increased progressively over 5 years; there was no significant difference between whites and nonwhites. As expected, ANA positivity was high and anti‐DNA positivity was relatively low at enrollment, and both increased over 5 years. Although lupus anticoagulant increased slightly over 5 years, aCL positivity did not.ConclusionDisease activity in newly diagnosed patients decreases over their first 5 years, while damage increases. Antibody positivity ran variable courses over this period. | en_US |
dc.description.sponsorship | Supported by the Canadian Institutes of Health Research,the Lupus Foundation of Ontario, Lupus UK, Lupus Ontario,the Conn Smythe Foundation, the Tolfo Family, and theLupus Foundation of America State Chapters of New Jersey,Long Island-Queens, Western New York, and Nashville.1M. B. Urowitz, MD, FRCP(C), D. D. Gladman, MD, D.Iban˜ ez, MSc, P. R. Fortin, MD: Toronto Western Hospital,Toronto, Ontario, Canada;2S. C. Bae, MD: Hospital forRheumatic Diseases and Hanyang University Medical Cen-ter, Seoul, South Korea;3C. Gordon, MD: University of Birmingham Medical School, Birmingham, UK;4A. Clarke,MD, S. Bernatsky, MD: Montreal General Hospital andMcGill University Health Centre, Montreal, Quebec, Can-ada;5J. G. Hanly, MD: Queen Elizabeth II Health SciencesCentre and Dalhousie University, Halifax, Nova Scotia,Canada;6D. Isenberg, MD: University College, London, UK | en_US |
dc.language.iso | en | en_US |
dc.publisher | JOHN WILEY | en_US |
dc.subject | antinuclear antibody | en_US |
dc.subject | cardiolipin antibody | en_US |
dc.subject | corticosteroid | en_US |
dc.subject | lupus anticoagulant | en_US |
dc.title | Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 64 | - |
dc.identifier.doi | 10.1002/acr.20648 | - |
dc.relation.page | 132-137 | - |
dc.relation.journal | ARTHRITIS CARE & RESEARCH | - |
dc.contributor.googleauthor | Urowitz, M.B. | - |
dc.contributor.googleauthor | Gladman, D.D. | - |
dc.contributor.googleauthor | Ibanez, D. | - |
dc.contributor.googleauthor | Fortin, P.R. | - |
dc.contributor.googleauthor | Bae, S.C. | - |
dc.contributor.googleauthor | Gordon, C. | - |
dc.contributor.googleauthor | Clarke, A. | - |
dc.contributor.googleauthor | Bernatsky, S. | - |
dc.contributor.googleauthor | Hanly, J.G. | - |
dc.contributor.googleauthor | Isenberg, D. | - |
dc.relation.code | 2012230765 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.researcherID | 55489131800 | - |
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