스펙트럼영역과 시간영역 빛간섭단층촬영기로 측정한 망막신경섬유층 두께 비교

Abstract

목적: 시간영역 빛간섭단층촬영기(stratus-optical coherence tomography)와 스펙트럼영역 빛간섭단층촬영기(3D-OCT)로 측정한 망막신경섬유층의 두께를 비교하였다. 대상과 방법: 정상 69안과 녹내장 92안을 대상으로 같은 날 Stratus-OCT의 fast RNFL scan과 3D-OCT의 optic disc cube scan으로 유두주위 망막신경섬유층 두께를 구하였고, 두 측정치의 연관성을 알아보기 위해 상관분석과 Bland-Altman plot을 이용하였다. 결과: 전 대상에서 평균, 상사분면, 하사분면 망막신경섬유층 두께는 Stratus-OCT가 3D-OCT보다 두꺼웠고, 반면에 이측사분면, 비측사분면에서는 3D가 Stratus보다 두꺼웠다. 두 기기 간에 절대치는 차이가 있었으나 상관계수는 높았다(r=0.678-0.905). Bland-Altmanplot에서 상대적으로 두꺼운 망막신경섬유층 두께에서는 Stratus-OCT가 3D-OCT보다 두껍게 측정되었고, 얇은 두께에서는 3D가 Stratus보다 두껍게 측정되었다. 결론: 두 기기의 측정치를 비교할 때 망막신경섬유층 두께에 따라 차이가 있음을 고려하여야 한다. <대한안과학회지 2012;53(1):103-110>Purpose: To compare retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (3D) optical coherence tomography (OCT). Methods: Sixty-nine normal subjects and 92 glaucoma patients were included in the present study. Peripapillary RNFL thickness was measured with Stratus fast RNFL scan and 3D optic disc cube scan on the same day. The relationship between RNFL thickness measurements of the two OCTs were evaluated using a Pearson`s correlation analysis. A Bland-Altman plot was used for the comparison of Stratus-OCT and 3D-OCT. Results: In all subjects, average, superior, and inferior quadrant RNFL thicknesses measured by Stratus-OCT were thicker than those measured by 3D-OCT. In contrast, temporal and nasal quadrant RNFL thicknesses measured by 3D-OCT were thicker than those measured by Stratus-OCT. Although there were absolute value differences in RNFL thicknesses, high correlation was observed between Stratus-OCT and 3D-OCT (average: r = 0.897, temporal quadrant: r = 0.728, superior quadrant: r = 0.811, nasal quadrant: r = 0.678, and inferior quadrant: r = 0.905). Bland-Altman plots showed that Stratus-OCT values were greater than 3D-OCT values with relatively high RNFL thickness and the opposite with low RNFL thickness. Conclusions: For thicker RNFL, Stratus-OCT measurements tend to be greater than 3D-OCT, while for thinner RNFL, 3D-OCT measurements tend to be greater than Stratus-OCT. This difference must be taken into account if comparing measurements made with a Stratus-OCT to the measurements of a 3D-OCT. J Korean Ophthalmol Soc 2012;53(1):103-110