Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최호진 | - |
dc.date.accessioned | 2018-04-15T15:26:55Z | - |
dc.date.available | 2018-04-15T15:26:55Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol.64, No.5 [2012], p756-p762 | en_US |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.2012.01460.x | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67047 | - |
dc.description.abstract | Objectives This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). Methods Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoicmembrane assay. Key findings In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeabilitymodel, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59 mg/ kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27 mg/ kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. Conclusions FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG. | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korea HealthcareTechnology R&D Project, Ministry of Health & Welfare,Republic of Korea (Grant No. A103017). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | anti-inflammatory | en_US |
dc.subject | antinociceptive | en_US |
dc.subject | Bifidobacterium | en_US |
dc.subject | fermentation | en_US |
dc.subject | red ginseng | en_US |
dc.title | Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/j.2042-7158.2012.01460.x | - |
dc.relation.journal | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.contributor.googleauthor | Jung, H. J. | - |
dc.contributor.googleauthor | Choi, H. | - |
dc.contributor.googleauthor | Lim, H. W. | - |
dc.contributor.googleauthor | Shin, D. | - |
dc.contributor.googleauthor | Kim, H. | - |
dc.contributor.googleauthor | Kwon, B. | - |
dc.contributor.googleauthor | Lee, J. E. | - |
dc.contributor.googleauthor | Park, E. H. | - |
dc.contributor.googleauthor | Lim, C. J. | - |
dc.relation.code | 2012205630 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chj | - |
dc.identifier.researcherID | 55724367200 | - |
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