Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
- Title
- Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
- Author
- 김진웅
- Keywords
- collagenase-1; triterpenoids; dihydroquercetin; photoageing; interleukin-8
- Issue Date
- 2012-05
- Publisher
- Springer Science + Business Media
- Citation
- Russian Journal of Bioorganic Chemistry, Vol.38, No.3 [2012], p328–334
- Abstract
- Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).
- URI
- http://link.springer.com/article/10.1134/S1068162012030028http://hdl.handle.net/20.500.11754/67016
- ISSN
- 1068-1620
- DOI
- 10.1134/S1068162012030028
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML