Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-04-15T14:27:30Z | - |
dc.date.available | 2018-04-15T14:27:30Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | MOLECULAR BIOLOGY REPORTS, Vol.39, No.5 [2012], p5599-p5605 | en_US |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs11033-011-1364-3 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67000 | - |
dc.description.abstract | The aim of this study was to explore whether the cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G polymorphism confers susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between CTLA-4 +49 A/G polymorphism and RA using; 1) allele contrast, 2) the recessive model, 3) the dominant model, and 4) an additive model. A total of 19 studies, 5,752 RA patients and 5,508 controls, encompassing 9 Caucasian, 8 Asian, 1 Mexican, and 1 Tunisian population were included in this meta-analysis. Ethnicity-specific meta-analysis was performed on Caucasian and Asian populations. Meta-analysis of the CTLA-4 +49 A/G polymorphism revealed an association between RA and the CTLA-4 +49 G allele in all 11,260 study subjects (odds ratio (OR) 1.118, 95% confidence interval (CI) 1.033-1.210, P = 0.005). Stratification by ethnicity showed an association between the CTLA-4 +49 G allele and RA in Asians (OR 1.164, 95% CI 1.056-1.283, P = 0.002), but no evidence of an association in Caucasians (OR 1.085, 95% CI 0.973-1.209, P = 0.431). Furthermore, associations were found between RA and the CTLA-4 +49 A/G polymorphism in Asians using the dominant and additive models, but not using the recessive model. On the other hand, no association was found between RA and the CTLA-4 +49 A/G polymorphism using the recessive, dominant, or additive models in Caucasians. This meta-analysis demonstrates that the CTLA-4 +49 A/G polymorphism confers susceptibility to RA in Asians, but not in Caucasians. | en_US |
dc.description.sponsorship | This study was supported by a grant of Korea University, College of Medicine, and a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | CTLA-4 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Association between the CTLA-4+49 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.1007/s11033-011-1364-3 | - |
dc.relation.page | 5599-5605 | - |
dc.relation.journal | MOLECULAR BIOLOGY REPORTS | - |
dc.contributor.googleauthor | Lee, Young-Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Choi, Sung-Jae | - |
dc.contributor.googleauthor | Ji, Jong-Dae | - |
dc.contributor.googleauthor | Song, Gwan-Gyu | - |
dc.relation.code | 2012206806 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.researcherID | 55489131800 | - |
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