Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정일엽 | - |
dc.date.accessioned | 2018-04-15T14:26:24Z | - |
dc.date.available | 2018-04-15T14:26:24Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | PHARMACOGENETICS AND GENOMICS, Vol.22, No.5 [2012], p327-p335 | en_US |
dc.identifier.issn | 1744-6872 | - |
dc.identifier.uri | https://journals.lww.com/jpharmacogenetics/Abstract/2012/05000/Association_between_WDR21A_polymorphisms_and.1.aspx | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66999 | - |
dc.description.abstract | Objective Genetic polymorphism is partially responsible for the wide variation in the response of moderate-to-severe asthmatic patients to inhaled corticosteroids. The goal of the study was to examine polymorphisms in WDR21A, which encodes a putative glucocorticoid receptor (GR)-interacting protein, for their possible association with corticosteroid responsiveness. Methods The change in forced expiratory volume in 1 s [FEV1 (Delta FEV1)] induced by 4 weeks of inhaled treatment with fluticasone propionate (1000 mu g daily) was measured in 230 asthmatic patients. Fifteen single nucleotide polymorphisms (SNPs) of WDR21A were genotyped using a TaqMan assay, and 11 SNPs were used for further analysis. WDR21A transcripts were analyzed for variant splicing using reverse transcriptase-PCR. The WDR21A protein structure was predicted using a template-based modeling method and docked to a GR using Zdock. Results Of the 11 SNPs and three haplotypes of WDR21A analyzed, only the intronic SNP -10073G>C appeared to affect Delta FEV1. The Delta FEV1 of the -10073C/C homozygous genotype was twice that of the -10073G/G and -10073C/G genotypes (P-corr = 0.04 in recessive model). No splicing variant of WDR21A was observed, regardless of genotype. The predicted WDR21A protein structure was similar to the G beta(1) protein structure (template modeling-score=0.93). Conclusion The minor allele -10073C of WDR21A may induce a good response to inhaled corticosteroids possibly through competition with the G beta(1) proteins for binding to GRs. Pharmacogenetics and Genomics 22:327-335 | en_US |
dc.description.sponsorship | DNA samples were generously provided by the Soonchunhyang University Bucheon Hospital Biobank, a member of the National Biobank of Korea, supported by the Ministry of Health, Welfare and Family Affairs, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | asthma | en_US |
dc.subject | corticosteroid | en_US |
dc.subject | G-protein beta subunit | en_US |
dc.subject | G-protein gamma subunit | en_US |
dc.subject | pharmacogenetics | en_US |
dc.subject | single nucleotide polymorphism | en_US |
dc.subject | WDR21A | en_US |
dc.title | Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 22 | - |
dc.identifier.doi | 10.1097/FPC.0b013e32834ef849 | - |
dc.relation.page | 327-335 | - |
dc.relation.journal | PHARMACOGENETICS AND GENOMICS | - |
dc.contributor.googleauthor | Cho, S.-H. | - |
dc.contributor.googleauthor | Park, B.-L. | - |
dc.contributor.googleauthor | Shin, S.W. | - |
dc.contributor.googleauthor | Heo, J.-S. | - |
dc.contributor.googleauthor | Park, J.-S. | - |
dc.contributor.googleauthor | Park, S.W. | - |
dc.contributor.googleauthor | Jang, A.-S. | - |
dc.contributor.googleauthor | Chung, I.Y. | - |
dc.contributor.googleauthor | Shin, H.-D. | - |
dc.contributor.googleauthor | Park, C.-S. | - |
dc.relation.code | 2012212606 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | iychu | - |
dc.identifier.researcherID | 15742259000 | - |
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