Recent trends in the treatment of chronic hepatitis C.
- Title
- Recent trends in the treatment of chronic hepatitis C.
- Author
- 전대원
- Keywords
- Chronic hepatits C; Pegylated interferon; Ribavirin; Response-guided therapy
- Issue Date
- 2012-05
- Publisher
- The Korean Association for the Study of the Liver, 2012.
- Citation
- The Korean journal of hepatology . v.18 no.1, 2012년, pp.22 - 28
- Abstract
- Pegylated interferon and ribavirin combination therapy is accepted as the standard antiviral treatment for chronic hepatitis C regardless of HCV genotype. This combination therapy achieves higher response rates than previous therapy, but, nevertheless, a large proportion of patients suffer from treatment failure or adverse events. Recent clinical studies of viral kinetics during antiviral treatment have led to the introduction of response-guided therapy, the concept of 'customized therapy depending on viral response', which focuses on modulation of the treatment period depending on the viral response to create a sustained viral response without unnecessary medication and costs. New upcoming direct-acting antivirals (DAAs) maximize response rate, and triple therapy including DAAs along with pegylated interferon and ribavirin combination therapy could soon be the standard therapy. In this article, we reviewed the factors affecting treatment, response guided treatment, retreatment after failure of standard treatment, management of adverse events during treatment, and new treatment options.
- URI
- https://www.e-cmh.org/journal/view.php?doi=10.3350/kjhep.2012.18.1.22http://hdl.handle.net/20.500.11754/66907
- ISSN
- 1226-0479
- DOI
- 10.3350/kjhep.2012.18.1.22
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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