Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신흥수 | - |
dc.date.accessioned | 2018-04-15T11:23:35Z | - |
dc.date.available | 2018-04-15T11:23:35Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | Macromolecular Research, 2011, 19(8), P.789-796(8) | en_US |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.issn | 2092-7673 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs13233-011-0815-y | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66858 | - |
dc.description.abstract | A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-epsilon-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequently immobilize gelatin (GD-PLCL). The D-PLCL matrices showed minimal changes in the mechanical properties with a tensile strain of 251.0 +/- 33.4% and 247.8 +/- 32.1% before and after the coating process, respectively. The cellular activities on the fibrous matrices increased in the order of PLCL<G-PLCL<D-PLCL<GD-PLCL; the H9c2 myoblasts on the GD-PLCL matrices showed approximately two-times higher adhesion and spreading than those on the PLCL matrices, and the proliferation was significantly greater on the GD-PLCL matrices than on the other matrices. Therefore, polydopamine can effectively immobilize the bioactive functional groups on the surface of electrospun fibrous matrices for the development of a tissue specific cell delivery carrier. | en_US |
dc.description.sponsorship | This work was supported by the WCU program funded by the Ministry of Education, Science and Technology, Korea (R332009000100360). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | surface modification | en_US |
dc.subject | polydopamine | en_US |
dc.subject | lectrospinning | en_US |
dc.subject | gelatin | en_US |
dc.title | Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1007/s13233-011-0815-y | - |
dc.relation.page | 835-842 | - |
dc.relation.journal | MACROMOLECULAR RESEARCH | - |
dc.contributor.googleauthor | Shin, Young-Min | - |
dc.contributor.googleauthor | Park, Han-Soo | - |
dc.contributor.googleauthor | Shin, Heung-Soo | - |
dc.relation.code | 2011210429 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | hshin | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.