Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이근용 | - |
dc.date.accessioned | 2018-04-15T10:29:39Z | - |
dc.date.available | 2018-04-15T10:29:39Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | Biomaterials, 2011, 32(28), P.6754-6763 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961211006430?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66808 | - |
dc.description.abstract | The mechanical properties of the cellular microenvironment dramatically alter during tissue development and growth. Growing evidence suggests that physical microenvironments and mechanical stresses direct cell fate in developing tissue. However, how these physical cues affect the tissue morphogenesis remains a major unknown. We explain here that the physical properties of the cell and tissue microenvironment, biomimetically reproduced by using hydrogel, guide the tissue morphogenesis in the developmental submandibular gland (SMG). In particular, the softer gel enhances the bud expansion and cleft formation of SMG, whereas the stiffer gel attenuates them. These morphological changes in SMG tissue are led by soluble factors (FGF7/10) induction regulated by cell traction force derived from the tissue deformation. Our findings suggest that cells sense the mechanics of their surrounding environment and alter their properties for self-organization and the following tissue morphogenesis. Also, physically designed hydrogel material is a valuable tool for producing the biomimetic microenvironment to explore how physical cues affect tissue morphogenesis and to modulate tissue morphogenesis for in vitro tissue synthesis. (C) 2011 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | The Authors are grateful to Prof. David Mooney (Harvard University) for his kind guidance of the material preparations (RGD-alginate). This work was supported by Grant-in-Aid for Scientific Research No. 19659503 from JSPS. The Authors are also grateful to Prof. Shigenori Nonaka (National Institute for Basic Biology, Japan) for useful discussion. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science LTD | en_US |
dc.subject | Biomimetic material | en_US |
dc.subject | Mechanical properties | en_US |
dc.subject | Alginate | en_US |
dc.subject | Salivary gland | en_US |
dc.subject | Morphogenesis | en_US |
dc.title | Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis | en_US |
dc.type | Article | en_US |
dc.relation.no | 28 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.05.072 | - |
dc.relation.page | 6754-6763 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Miyajima, H. | - |
dc.contributor.googleauthor | Matsumoto, T. | - |
dc.contributor.googleauthor | Sakai, T. | - |
dc.contributor.googleauthor | Yamaguchi, S. | - |
dc.contributor.googleauthor | An, S. H. | - |
dc.contributor.googleauthor | Abe, M. | - |
dc.contributor.googleauthor | Wakisaka, S. | - |
dc.contributor.googleauthor | Lee, K. Y. | - |
dc.contributor.googleauthor | Egusa, H. | - |
dc.contributor.googleauthor | Imazato, S. | - |
dc.relation.code | 2011201314 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | leeky | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.