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Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis

Title
Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis
Author
이근용
Keywords
Biomimetic material; Mechanical properties; Alginate; Salivary gland; Morphogenesis
Issue Date
2011-08
Publisher
Elsevier Science LTD
Citation
Biomaterials, 2011, 32(28), P.6754-6763
Abstract
The mechanical properties of the cellular microenvironment dramatically alter during tissue development and growth. Growing evidence suggests that physical microenvironments and mechanical stresses direct cell fate in developing tissue. However, how these physical cues affect the tissue morphogenesis remains a major unknown. We explain here that the physical properties of the cell and tissue microenvironment, biomimetically reproduced by using hydrogel, guide the tissue morphogenesis in the developmental submandibular gland (SMG). In particular, the softer gel enhances the bud expansion and cleft formation of SMG, whereas the stiffer gel attenuates them. These morphological changes in SMG tissue are led by soluble factors (FGF7/10) induction regulated by cell traction force derived from the tissue deformation. Our findings suggest that cells sense the mechanics of their surrounding environment and alter their properties for self-organization and the following tissue morphogenesis. Also, physically designed hydrogel material is a valuable tool for producing the biomimetic microenvironment to explore how physical cues affect tissue morphogenesis and to modulate tissue morphogenesis for in vitro tissue synthesis. (C) 2011 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0142961211006430?via%3Dihubhttp://hdl.handle.net/20.500.11754/66808
ISSN
0142-9612
DOI
10.1016/j.biomaterials.2011.05.072
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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