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The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis

Title
The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis
Author
배상철
Keywords
Interleukin-6; Polymorphism; Rheumatoid arthritis; Meta-analysis
Issue Date
2012-07
Publisher
Springer Science + Business Media
Citation
Inflammation research, 2012, 61(7), P.665-671
Abstract
ObjectiveThe aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter −174 G/C and −572 G/C polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.MethodsMeta-analysis was conducted on the associations between these IL-6 polymorphisms and RA.ResultsA total of nine studies involving 3,851 subjects (RA 2,053 and controls 1,798) were considered in this study and ethnicity-specific meta-analysis was performed on European subjects. In all study subjects, meta-analysis revealed a trend toward to an association between RA and the IL-6 −174 G allele (odds ratio [OR] = 0.699, 95 % confidence interval [CI] = 0.463–1.054, p = 0.088). Stratification by ethnicity indicated a significant association between RA and the IL-6 −174 G/C polymorphism in Europeans using the dominant (OR = 0.329, 95 % CI = 0.155–0.699, p = 0.004) and recessive (OR = 0.823, 95 % CI = 0.679–0.997, p = 0.047) models. Meta-analysis of the IL-6 −572 G/C polymorphism showed no association between RA and the IL-6 −572 G allele in all study subjects (OR = 1.641, 95 % CI = 0.613–4.397, p = 0.324).ConclusionsThis meta-analysis shows that the IL-6 −174 G/C polymorphism may confer susceptibility to RA in Europeans.
URI
https://link.springer.com/article/10.1007%2Fs00011-012-0459-1http://hdl.handle.net/20.500.11754/66418
ISSN
1023-3830
DOI
10.1007/s00011-012-0459-1
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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