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dc.contributor.author정승준-
dc.date.accessioned2018-04-14T14:39:45Z-
dc.date.available2018-04-14T14:39:45Z-
dc.date.issued2012-07-
dc.identifier.citationProceedings of the National Academy of Sciences, 2012, 109(28), P.11378en_US
dc.identifier.issn0027-8424-
dc.identifier.urihttp://www.pnas.org/content/109/28/11378-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/66353-
dc.description.abstractDecreased neuronal dendrite branching and plasticity of the hippocampus, a limbic structure implicated in mood disorders, is thought to contribute to the symptoms of depression. However, the mechanisms underlying this effect, as well as the actions of antidepressant treatment, remain poorly characterized. Here, we show that hippocampal expression of neuritin, an activity-dependent gene that regulates neuronal plasticity, is decreased by chronic unpredictable stress (CUS) and that antidepressant treatment reverses this effect. We also show that viral-mediated expression of neuritin in the hippocampus produces antidepressant actions and prevents the atrophy of dendrites and spines, as well as depressive and anxiety behaviors caused by CUS. Conversely, neuritin knockdown produces depressive-like behaviors, similar to CUS exposure. The ability of neuritin to increase neuroplasticity is confirmed in models of learning and memory. Our results reveal a unique action of neuritin in models of stress and depression, and demonstrate a role for neuroplasticity in antidepressant treatment response and related behaviors.en_US
dc.language.isoenen_US
dc.publisherNational Academy of Sciences; 1999en_US
dc.subjectdespairen_US
dc.subjectanhedoniaen_US
dc.subjectBDNFen_US
dc.subjectsynaptogenesisen_US
dc.titleNeuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stressen_US
dc.typeArticleen_US
dc.relation.no28-
dc.relation.volume109-
dc.identifier.doi10.1073/pnas.1201191109-
dc.relation.page11378-11383-
dc.relation.journalPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.contributor.googleauthorSonSon, H.Banasr, M.Choi, M.Chae, S.Y.Licznerski, P.Lee, B.Voleti, B.Li, N.Lepack, A.Fournier, N.M. H.-
dc.contributor.googleauthorBanasr, M.-
dc.contributor.googleauthorChoi, M.-
dc.contributor.googleauthorChae, S.Y.-
dc.contributor.googleauthorLicznerski, P.-
dc.contributor.googleauthorLee, B.-
dc.contributor.googleauthorVoleti, B.-
dc.contributor.googleauthorLi, N.-
dc.contributor.googleauthorLepack, A.-
dc.contributor.googleauthorFournier, N.M.-
dc.relation.code2012207877-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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