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Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress

Title
Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
Author
정승준
Keywords
despair; anhedonia; BDNF; synaptogenesis
Issue Date
2012-07
Publisher
National Academy of Sciences; 1999
Citation
Proceedings of the National Academy of Sciences, 2012, 109(28), P.11378
Abstract
Decreased neuronal dendrite branching and plasticity of the hippocampus, a limbic structure implicated in mood disorders, is thought to contribute to the symptoms of depression. However, the mechanisms underlying this effect, as well as the actions of antidepressant treatment, remain poorly characterized. Here, we show that hippocampal expression of neuritin, an activity-dependent gene that regulates neuronal plasticity, is decreased by chronic unpredictable stress (CUS) and that antidepressant treatment reverses this effect. We also show that viral-mediated expression of neuritin in the hippocampus produces antidepressant actions and prevents the atrophy of dendrites and spines, as well as depressive and anxiety behaviors caused by CUS. Conversely, neuritin knockdown produces depressive-like behaviors, similar to CUS exposure. The ability of neuritin to increase neuroplasticity is confirmed in models of learning and memory. Our results reveal a unique action of neuritin in models of stress and depression, and demonstrate a role for neuroplasticity in antidepressant treatment response and related behaviors.
URI
http://www.pnas.org/content/109/28/11378http://hdl.handle.net/20.500.11754/66353
ISSN
0027-8424
DOI
10.1073/pnas.1201191109
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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