Release Kinetics and in vitro Bioactivity of Basic Fibroblast Growth Factor: Effect of the Thickness of Fibrous Matrices
- Title
- Release Kinetics and in vitro Bioactivity of Basic Fibroblast Growth Factor: Effect of the Thickness of Fibrous Matrices
- Author
- 김선일
- Keywords
- basic fibroblast growth factors; electrospinning; human mesenchymal stem cells; human umbilical vein endothelial cells; tissue engineering
- Issue Date
- 2011-01
- Publisher
- WILEY-V C H VERLAG GMBH, PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
- Citation
- MACROMOLECULAR BIOSCIENCE 권: 11 호: 1 페이지: 122-130
- Abstract
- In this study, we fabricated non-woven matrices using blends of polycaprolactone and gelatin with various spinning volumes to control the immobilized heparin content, which was ultimately intended to increase the immobilization efficiency of bFGF. The amount of bFGF on the heparin conjugated fibrous matrices depended on the thicknesses of the swollen matrices ranging from 35.4 +/- 6.5 to 162.3 +/- 14.0 ng and approximate to 90% of the bFGF was gradually released over a period of up to 56 d. The released bFGF enhanced the proliferation of human umbilical vein endothelial cells and human mesenchymal stem cells. In conclusion, our heparin-conjugated fibrous matrices have the potential to be used as a growth factor delivery system in tissue engineering applications.
- URI
- http://onlinelibrary.wiley.com/doi/10.1002/mabi.201000222/abstracthttp://hdl.handle.net/20.500.11754/65938
- ISSN
- 1616-5187; 1616-5195
- DOI
- 10.1002/mabi.201000222
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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