Magnetic model for a horse-spleen ferritin with a three-phase core structure

Abstract

The increasing interests in magnetic nanoparticles has prompted research on ferritin, which is naturally a well-defined iron-storage protein in most living organisms. However, the exact magnetic behavior of ferritin is not well understood, because the crystal structures of ferritin and ferrihydrite, its major component, are not fully understood. Briefly, we discuss the previous magnetization models of ferritin and ferrihydrite and we present a new model (Σ3L) of the initial magnetization of ferritin, considering its different phases. The new model includes three Langevin-function terms, which represent three different magnetic moments provided by the likely hydroxide and oxide mineral phases in ferritin. Compared to previous models, our simple model fits the experimental data 12 times better in terms of the sum of least squares. The magnetic independence of each component supports the multi-phase compositional model of the mineral core of horse-spleen ferritin. This Σ3L model gives a quantization of the amounts of the different phases within horse-spleen ferritins that matches other published experimental data: 60–80% ferrihydrite, 15–25% maghemite/magnetite, and 1–10% hematite.