Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
- Title
- Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
- Author
- 오영하
- Keywords
- Programmed death-1 (PD-1); Lymphoma; Prognostic factor; diffuse; Lymphoma; large B-cell
- Issue Date
- 2011-12
- Publisher
- 대한병리학회
- Citation
- Journal of Pathology and Translational Medicine, 2011, 45(6), P.573-581, 9P.
- Abstract
- Background: Programmed death-1 (PD-1) is physiologically expressed by germinal center-asso-ciated helper T-cells and has an inhibitory effect on T-cell activity. Methods: We examined 63 cas¬es of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal an¬tibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400×). Results: Patients were divided into 2 groups: one with a high number of PD-1-positive cells (〉20/HPF, n=33) and one with a low number of PD-1-positive cells (≤20/HPF, n=30). The for¬mer group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score. Conclusions: The high number of PD-1-positive cells might be associated with an unfavorable outcome in DL¬BCL patients.
- URI
- https://www.jpatholtm.org/journal/view.php?number=3014http://hdl.handle.net/20.500.11754/65782
- DOI
- 10.4132/KoreanJPathol.2011.45.6.573
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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