78 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author최한곤-
dc.date.accessioned2018-04-12T02:50:08Z-
dc.date.available2018-04-12T02:50:08Z-
dc.date.issued2016-07-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 511, No. 1, Page. 351-358en_US
dc.identifier.issn0378-5173-
dc.identifier.issn1873-3476-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517316306366-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/65627-
dc.description.abstractThe purpose of this study was to compare the powder properties, solubility, dissolution and oral absorption of solvent-wetted (SWSD) and kneaded (KNSD) L-sulpiride-loaded solid dispersions. The SWSD and KNSD were prepared with silicon dioxide, sodium laurylsulfate and D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) using a spray dryer and high shear mixer, respectively. Their powder properties, solubility, dissolution and oral absorption were assessed compared to L-sulpiride powder. The drug in SWSD was in the amorphous state; however, in KNSD, it existed in the crystalline state. The SWSD with a drug/sodium laurylsulphate/TPGS/silicon dioxide ratio of 5/1/2/12 gave the higher drug solubility and dissolution compared to the KNSD with the same composition. The oral absorption of drug in the SWSD was 1.4 fold higher than the KNSD and 3.0 fold higher than the L-sulpiride powder (p < 0.05) owing to better solubility and reduced crystallinity. Furthermore, the SWSD at the half dose was bioequivalent of commercial L-sulpiride-loaded product in rats. Thus, the SWSD with more improved oral absorption would be recommended as an alternative for the L-sulpiride-loaded oral administration. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of South Korea (NRF) grant funded by the South Korea government (MEST) (No. 2015R1A2A2A05027872).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectL-Sulpirideen_US
dc.subjectTPGS-based solid dispersionen_US
dc.subjectSolvent-wetteden_US
dc.subjectKneadeden_US
dc.subjectOral absorptionen_US
dc.titleComparison of solvent-wetted and kneaded L-sulpiride-loaded solid dispersions: Powder characterization and in vivo evaluationen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume511-
dc.identifier.doi10.1016/j.ijpharm.2016.07.006-
dc.relation.page351-358-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorKim, DS-
dc.contributor.googleauthorChoi, JS-
dc.contributor.googleauthorKim, DW-
dc.contributor.googleauthorKim, KS-
dc.contributor.googleauthorSeo, YG-
dc.contributor.googleauthorCho, KH-
dc.contributor.googleauthorKim, JO-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorYoun, YS-
dc.contributor.googleauthorChoi, HG-
dc.contributor.googleauthorLim, SJ-
dc.contributor.googleauthorJin, SG-
dc.relation.code2016002676-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE