Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손현 | - |
dc.date.accessioned | 2018-04-04T01:09:35Z | - |
dc.date.available | 2018-04-04T01:09:35Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | PLOS ONE, 9권, 10호, 논문번호 e109253 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109253 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/58491 | - |
dc.description.abstract | Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 and hGATA-2) are linked to neuronal differentiation and depressive behaviors in rats. We investigated the effects of adeno-associated viral expression of hGATA-1 and hGATA-2 (AAV-hGATA1 and AAV-hGATA2) in the dentate gyrus (DG) of the dorsal hippocampus on dendrite branching and spine number. We also examined the influence of AAV-hGATA1 and AAV-hGATA2 infusions into the dorsal hippocampus on rodent behavior in models of depression. Viral expression of hGATA-1 and hGATA-2 cDNA in rat hippocampal neurons impaired dendritic outgrowth and spine formation. Moreover, viral-mediated expression of hGATA-1 and hGATA-2 in the dorsal hippocampus caused depressive-like deficits in the forced swim test and learned helplessness models of depression, and decreased the expression of several synapse-related genes as well as spine number in hippocampal neurons. Conversely, shRNA knockdown of GATA-2 increased synapse-related gene expression, spine number, and dendrite branching. The results demonstrate that hGATA-1 and hGATA-2 expression in hippocampus is sufficient to cause depressive like behaviors that are associated with reduction in spine synapse density and expression of synapserelated genes. | en_US |
dc.description.sponsorship | National Research Foundation grant of Kprea (No. 2011-0028317) funded by Korea government awarded to HS. | en_US |
dc.language.iso | other | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE, 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA | en_US |
dc.subject | ANTIDEPRESSANT ACTIONS | en_US |
dc.subject | TRANSCRIPTION FACTORS | en_US |
dc.subject | DENDRITIC SPINES | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.subject | BRAIN | en_US |
dc.title | Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1371/journal.pone.0109253 | - |
dc.relation.page | 1-2 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | Choi, Miyeon | - |
dc.contributor.googleauthor | Wang, Sung Eun | - |
dc.contributor.googleauthor | Ko, Seung Yeon | - |
dc.contributor.googleauthor | Kang, Hyo Jung | - |
dc.contributor.googleauthor | Chae, Seung Yeun | - |
dc.contributor.googleauthor | Lee, Seung Hoon | - |
dc.contributor.googleauthor | Kim, Yong-Seok | - |
dc.contributor.googleauthor | Duman, Ronald S. | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2014037807 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyeonson | - |
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