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Association of a Functional IRF7 Variant With Systemic Lupus Erythematosus
- Title
- Association of a Functional IRF7 Variant With Systemic Lupus Erythematosus
- Author
- 조수경
- Keywords
- Adult; African Americans; genetics; statistics & numerical data; Amino Acid Sequence; Asian Continental Ancestry Group; Ethnic Groups; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; epidemiology; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Interferon Regulatory Factor-7; immunology; Lupus Erythematosus; Systemic; ethnology; Male; Molecular Sequence Data; Polymorphism; Single Nucleotide; Risk Factors
- Issue Date
- 2011-03
- Publisher
- Wiley
- Citation
- Arthritis and rheumatism, Vol.63, No.3 [2011], pp. 749-754
- Abstract
- A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE). This study was undertaken to investigate whether genetic polymorphism within IRF7 is a risk factor for the development of SLE.
- URI
- https://onlinelibrary.wiley.com/doi/abs/10.1002/art.30193http://hdl.handle.net/20.500.11754/57572
- ISSN
- 0004-3591
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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