Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors
- Title
- Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors
- Author
- 심지원
- Keywords
- EMBRYONIC STEM-CELLS; NUCLEAR-PORE; HEMATOPOIETIC PROGENITORS; GENE-REGULATION; BTB/POZ DOMAIN; ACUTE-LEUKEMIA; LYMPH GLAND; NUP98 GENE; PROTEIN; IDENTIFICATION
- Issue Date
- 2014-09
- Publisher
- ELIFE SCIENCES PUBLICATIONS LTD, SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
- Citation
- ELIFE, 2014, 3(), P. 1-18
- Abstract
- Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the "equilibrium signal" in order to distinguish it from the "niche signal". Earlier we showed that Equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and Adenosine deaminase-related growth factor A (ADGF-A) [1]. Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric brac interacting protein 1) and Nucleoporin (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.
- URI
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185420/http://hdl.handle.net/20.500.11754/57355
- ISSN
- 2050-084X
- DOI
- 10.7554/eLife.03626
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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