A single nucleotide polymorphism in the phospholipase D1 gene is associated with risk of non-small cell lung cancer
- Title
- A single nucleotide polymorphism in the phospholipase D1 gene is associated with risk of non-small cell lung cancer
- Author
- 김원규
- Keywords
- DGGE; NSCLC; biomarker; lung cancer; phospholipase D; single nucleotide polymorphism.
- Issue Date
- 2012-06
- Publisher
- Master Publishing Group
- Citation
- International Journal of Biomedical Science, June 2012, 8(2), P.121~128
- Abstract
- Phospholipase D (PLD) has an important role in various biological functions including vesicular transport, endocytosis, exocytosis, cell migration, and mitosis. These cellular biological processes are deregulated in the development of various human tumors. In order to explore the relationship between the PLD1 gene and risk of non-small cell lung cancer (NSCLC), single nucleotide polymorphisms (SNP) in the PLD1 exon region were surveyed in 211 NSCLC patients and 205 normal controls. In this study, we identified six SNPs at exon 23 in the PLD1 gene. Among the six SNPs, the most notable was a heterozygous A to C transition at nucleotide 2698 (A2698C, p
- URI
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614861/http://hdl.handle.net/20.500.11754/55140
- ISSN
- 1550-9702; 1555-2810
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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