Polarization-extinction-based detection of DNA hybridization in situ using a nanoparticle wire-grid polarizer
- Title
- Polarization-extinction-based detection of DNA hybridization in situ using a nanoparticle wire-grid polarizer
- Author
- 송석호
- Keywords
- PLASMON RESONANCE DETECTION; FABRICATION; GRATINGS; SENSOR; GLASS
- Issue Date
- 2012-11
- Publisher
- OPTICAL SOC AMER, 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
- Citation
- OPTICS LETTERS, SEP 15 2012,Vol.37,No.18, p3867-p3869, 3p.
- Abstract
- Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.
- URI
- https://www.osapublishing.org/ol/abstract.cfm?uri=ol-37-18-3867http://hdl.handle.net/20.500.11754/55121
- ISSN
- 0146-9592
- DOI
- 10.1364/OL.37.003867
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > PHYSICS(물리학과) > Articles
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