Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
- Title
- Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
- Author
- 채필석
- Keywords
- Carbohydrates; chemistry; Detergents; Membrane Proteins; Micelles; Octoxynol; Protein Stability; Solubility; Surface-Active Agents
- Issue Date
- 2013-04
- Publisher
- ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
- Citation
- Molecular bioSystems v.9 no.4 ,pp. 626 - 629 , 2013
- Abstract
- Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
- URI
- http://dx.doi.org/10.1039/c3mb25584khttp://hdl.handle.net/20.500.11754/54566
- ISSN
- 1742-206X
- DOI
- 10.1039/c3mb25584k
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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