172 0

Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration

Title
Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration
Other Titles
Microsphere Aggregate as an Injectable for Tissue Regeneration
Author
이근용
Keywords
aggregate; alginate; cartilage regeneration; microsphere; tissue engineering
Issue Date
2014-05
Publisher
WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Citation
MACROMOLECULAR BIOSCIENCE, 2014, 14(5), P.740-748
Abstract
njectable delivery systems have been widely used in tissue engineering as they can deliver cells into the body in a minimally invasive manner. In this study, it is hypothesized that microspheres with a similar size of cells could effectively form a shear reversible aggregate in the presence of cells and the aggregate could be useful to engineer tissues. Alginate microspheres are prepared by an emulsion method, followed by modification with a peptide containing the arginine-glycine-aspartic acid (RGD) sequence. RGD-modified alginate microspheres form an aggregate in the presence of chondrocytes, and the aggregation behavior is shear reversible. This cell/microsphere aggregate is useful to deliver chondrocytes into an animal model using a syringe, and effectively regenerates cartilage tissues in vivo.
URI
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201300365/abstract;jsessionid=44811832F5118DA9803E349C6AD1DD6E.f01t03http://hdl.handle.net/20.500.11754/54469
ISSN
1616-5187; 1616-5195
DOI
10.1002/mabi.201300365
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE