Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박동원 | - |
dc.date.accessioned | 2018-03-30T08:17:06Z | - |
dc.date.available | 2018-03-30T08:17:06Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | JOURNAL OF CRITICAL CARE, 2014, 29(5), P.882.e5–882.e11 | en_US |
dc.identifier.issn | 0883-9441 | - |
dc.identifier.issn | 1557-8615 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0883944114002044 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/54465 | - |
dc.description.abstract | Purpose: The purpose of this study is to investigate the effect of serial lysophosphatidylcholine (LPC) measurement on 28-day mortality prediction in patients with severe sepsis or septic shock admitted to the medical intensive care unit (ICU). Methods: This is a prospective observational study of 74 ICU patients in a tertiary hospital. Serum LPC, white blood cell, C-reactive protein, and procalcitonin (PCT) levels were measured at baseline (day 1 of enrollment) and day 7. The LPC concentrations were compared with inflammatory markers using their absolute levels and relative changes. Results: The LPC concentration on day 7 was significantly lower in nonsurvivors than in survivors (68.45 +/- 42.36 mu mol/L and 99.76 +/- 73.65 mu mol/L; P = .04). A decreased LPC concentration on day 7 to its baseline as well as a sustained high concentration of PCT on day 7 at more than 50% of its baseline value was useful for predicting the 28-day mortality. Prognostic utility was substantially improved when combined LPC and PCT criteria were applied to 28-day mortality outcome predictions. Furthermore, LPC concentrations increased over time in patients with appropriate antibiotics but not in those with inappropriate antibiotics. Conclusions: Serial measurements of LPC help in the prediction of 28-day mortality in ICU patients with severe sepsis or septic shock. (C) 2014 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government Ministry of Science, ICT, and Future Planning (MSIP) (No. 2005-0049489). | en_US |
dc.language.iso | en | en_US |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC, 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA | en_US |
dc.subject | Lysophosphatidylcholine | en_US |
dc.subject | Mortality | en_US |
dc.subject | Severe sepsis | en_US |
dc.subject | Septic shock | en_US |
dc.subject | Intensive care unit | en_US |
dc.title | Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock | en_US |
dc.type | Article | en_US |
dc.relation.volume | 29 | - |
dc.identifier.doi | 10.1016/j.jcrc.2014.05.003 | - |
dc.relation.page | 882-882 | - |
dc.relation.journal | JOURNAL OF CRITICAL CARE | - |
dc.contributor.googleauthor | Park, Dong Won | - |
dc.contributor.googleauthor | Kwak, Dong Shin | - |
dc.contributor.googleauthor | Park, Yun Young | - |
dc.contributor.googleauthor | Chang, Youjin | - |
dc.contributor.googleauthor | Huh, Jin Won | - |
dc.contributor.googleauthor | Lim, Chae-Man | - |
dc.contributor.googleauthor | Koh, Younsuck | - |
dc.contributor.googleauthor | Song, Dong-Keun | - |
dc.contributor.googleauthor | Hong, Sang-Bum | - |
dc.relation.code | 2014032898 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | dongwonpark | - |
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