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dc.contributor.author박동원-
dc.date.accessioned2018-03-30T08:17:06Z-
dc.date.available2018-03-30T08:17:06Z-
dc.date.issued2014-05-
dc.identifier.citationJOURNAL OF CRITICAL CARE, 2014, 29(5), P.882.e5–882.e11en_US
dc.identifier.issn0883-9441-
dc.identifier.issn1557-8615-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0883944114002044-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/54465-
dc.description.abstractPurpose: The purpose of this study is to investigate the effect of serial lysophosphatidylcholine (LPC) measurement on 28-day mortality prediction in patients with severe sepsis or septic shock admitted to the medical intensive care unit (ICU). Methods: This is a prospective observational study of 74 ICU patients in a tertiary hospital. Serum LPC, white blood cell, C-reactive protein, and procalcitonin (PCT) levels were measured at baseline (day 1 of enrollment) and day 7. The LPC concentrations were compared with inflammatory markers using their absolute levels and relative changes. Results: The LPC concentration on day 7 was significantly lower in nonsurvivors than in survivors (68.45 +/- 42.36 mu mol/L and 99.76 +/- 73.65 mu mol/L; P = .04). A decreased LPC concentration on day 7 to its baseline as well as a sustained high concentration of PCT on day 7 at more than 50% of its baseline value was useful for predicting the 28-day mortality. Prognostic utility was substantially improved when combined LPC and PCT criteria were applied to 28-day mortality outcome predictions. Furthermore, LPC concentrations increased over time in patients with appropriate antibiotics but not in those with inappropriate antibiotics. Conclusions: Serial measurements of LPC help in the prediction of 28-day mortality in ICU patients with severe sepsis or septic shock. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government Ministry of Science, ICT, and Future Planning (MSIP) (No. 2005-0049489).en_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INC, 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USAen_US
dc.subjectLysophosphatidylcholineen_US
dc.subjectMortalityen_US
dc.subjectSevere sepsisen_US
dc.subjectSeptic shocken_US
dc.subjectIntensive care uniten_US
dc.titleImpact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shocken_US
dc.typeArticleen_US
dc.relation.volume29-
dc.identifier.doi10.1016/j.jcrc.2014.05.003-
dc.relation.page882-882-
dc.relation.journalJOURNAL OF CRITICAL CARE-
dc.contributor.googleauthorPark, Dong Won-
dc.contributor.googleauthorKwak, Dong Shin-
dc.contributor.googleauthorPark, Yun Young-
dc.contributor.googleauthorChang, Youjin-
dc.contributor.googleauthorHuh, Jin Won-
dc.contributor.googleauthorLim, Chae-Man-
dc.contributor.googleauthorKoh, Younsuck-
dc.contributor.googleauthorSong, Dong-Keun-
dc.contributor.googleauthorHong, Sang-Bum-
dc.relation.code2014032898-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.piddongwonpark-
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COLLEGE OF MEDICINE[S](의과대학) > ETC
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