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Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock

Title
Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock
Author
박동원
Keywords
Lysophosphatidylcholine; Mortality; Severe sepsis; Septic shock; Intensive care unit
Issue Date
2014-05
Publisher
W B SAUNDERS CO-ELSEVIER INC, 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
Citation
JOURNAL OF CRITICAL CARE, 2014, 29(5), P.882.e5–882.e11
Abstract
Purpose: The purpose of this study is to investigate the effect of serial lysophosphatidylcholine (LPC) measurement on 28-day mortality prediction in patients with severe sepsis or septic shock admitted to the medical intensive care unit (ICU). Methods: This is a prospective observational study of 74 ICU patients in a tertiary hospital. Serum LPC, white blood cell, C-reactive protein, and procalcitonin (PCT) levels were measured at baseline (day 1 of enrollment) and day 7. The LPC concentrations were compared with inflammatory markers using their absolute levels and relative changes. Results: The LPC concentration on day 7 was significantly lower in nonsurvivors than in survivors (68.45 +/- 42.36 mu mol/L and 99.76 +/- 73.65 mu mol/L; P = .04). A decreased LPC concentration on day 7 to its baseline as well as a sustained high concentration of PCT on day 7 at more than 50% of its baseline value was useful for predicting the 28-day mortality. Prognostic utility was substantially improved when combined LPC and PCT criteria were applied to 28-day mortality outcome predictions. Furthermore, LPC concentrations increased over time in patients with appropriate antibiotics but not in those with inappropriate antibiotics. Conclusions: Serial measurements of LPC help in the prediction of 28-day mortality in ICU patients with severe sepsis or septic shock. (C) 2014 Elsevier Inc. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0883944114002044http://hdl.handle.net/20.500.11754/54465
ISSN
0883-9441; 1557-8615
DOI
10.1016/j.jcrc.2014.05.003
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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