Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2018-03-30T07:25:13Z | - |
dc.date.available | 2018-03-30T07:25:13Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2014, 18(12), P.1407-1414 | en_US |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.issn | 1815-7920 | - |
dc.identifier.uri | http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000012/art00006 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/54432 | - |
dc.description.abstract | SETTING: Frequent exacerbation is an important phenotype in chronic obstructive pulmonary disease (COPD), while emphysema is associated with many comorbidities and lung function decline.OBJECTIVE: To investigate unique features of frequent exacerbators and test the hypothesis that emphysematous phenotype is associated with frequent exacerbations of COPD.METHODS: A total of 380 COPD patients were recruited from 16 hospitals in Korea from June 2005 to April 2012 for analysis. We searched for independent predictors of frequent exacerbators in comparison with non-exacerbators.RESULTS: As the severity of emphysema increased, forced expiratory volume in 1 s (FEV1), and FEV1/FVC (forced volume capacity) worsened; hyperinflationary features characterised by higher total lung capacity (TLC) were observed (P < 0.05). Frequent cxacerbators had lower body mass index (BMI), higher St George's Respiratory Questionnaire (SGRQ) scores, higher residual volume (RV)/TLC, more severe airflow limitation (lower FEVi and FEVi/FVC), lower carbon monoxide diffusion capacity, lower serum protein levels and a higher emphysema index than non-exacerbators (P < 0.05). In multivariate analysis, frequent exacerbators were independently associated with a higher emphysema index, lower serum protein levels and higher RV/TLC (P < 0.05).CONCLUSION: Our data show that the severity of emphysema, severe static hyperinflation and serum lower protein levels are independent predictors of frequent exacerbations in COPD patients. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health And Welfare (A102065), Seoul, Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | en_US |
dc.subject | emphysema | en_US |
dc.subject | frequent exacerbation | en_US |
dc.title | Emphysematous phenotype is an independent predictor for frequent exacerbation of COPD | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.5588/ijtld.14.0205 | - |
dc.relation.page | 1407-1414 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.contributor.googleauthor | Kim, T-H. | - |
dc.contributor.googleauthor | Sheen, S-S | - |
dc.contributor.googleauthor | Park, J. H. | - |
dc.contributor.googleauthor | Jin, U. R. | - |
dc.contributor.googleauthor | Yoo, J-W. | - |
dc.contributor.googleauthor | Seo, J. B. | - |
dc.contributor.googleauthor | Yoo, K. H. | - |
dc.contributor.googleauthor | Lee, J-H. | - |
dc.contributor.googleauthor | Oh, Y-M. | - |
dc.contributor.googleauthor | Lim, S. Y. | - |
dc.relation.code | 2014031833 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | drterry | - |
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