Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteria
- Title
- Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteria
- Author
- 안주홍
- Keywords
- calcineurin; calreticulin; calnexin; innate immunity
- Issue Date
- 2014-11
- Publisher
- Korean Society for Integrative Biology
- Citation
- Animal Cells and Systems, 2014, 18(6), P.394~398
- Abstract
- Innate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host?pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes.
- URI
- https://www.tandfonline.com/doi/abs/10.1080/19768354.2014.972981http://hdl.handle.net/20.500.11754/54377
- ISSN
- 1976-8354; 2151-2485
- DOI
- 10.1080/19768354.2014.972981
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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