Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경수 | - |
dc.date.accessioned | 2018-03-30T05:55:01Z | - |
dc.date.available | 2018-03-30T05:55:01Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | Cell Transplant. 2015, 24(10), P.2055-2119 | en_US |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | http://journals.sagepub.com/doi/10.3727/096368914X685609 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/54339 | - |
dc.description.abstract | Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-AECs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-AECs express these proangiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-AECs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. In conclusion, h-AECs secreted proangiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-AECs could regenerate myocardial tissue and improve cardiac function. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Medline | en_US |
dc.subject | Amniotic epithelial cells | en_US |
dc.subject | Myocardial infarction (MI) | en_US |
dc.subject | Paracrine | en_US |
dc.subject | Cytokine | en_US |
dc.title | Transplanted human amniotic epithelial cells secrete paracrine pro-angiogenic cytokines in rat model of myocardial infarction | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3727/096368914X685609 | - |
dc.relation.page | 1-27 | - |
dc.relation.journal | CELL TRANSPLANTATION | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | Joo, Hyun-Woo | - |
dc.contributor.googleauthor | Park, In-Hwa | - |
dc.relation.code | 2014026957 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kskim | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.