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NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

Title
NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides
Author
윤소원
Keywords
N-HETEROCYCLIC CARBENE; STETTER-ALDOL-MICHAEL; AROMATIC-ALDEHYDES; AEROBIC CONDITIONS; ASYMMETRIC ORGANOCATALYSIS; ALKYL-HALIDES; ESTERIFICATION; ALCOHOLS; ACID; HYDROACYLATION
Issue Date
2014-04
Publisher
ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Citation
Organic & Biomolecular Chemistry , 2014, 12(15), p.2388-2393
Abstract
An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.
URI
http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C3OB42546K#!divAbstracthttp://hdl.handle.net/20.500.11754/54086
ISSN
1477-0520; 1477-0539
DOI
10.1039/c3ob42546k
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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