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dc.contributor.author남진우-
dc.date.accessioned2018-03-28T07:19:58Z-
dc.date.available2018-03-28T07:19:58Z-
dc.date.issued2012-12-
dc.identifier.citationGenome research,22권, 12호,2529p ~ 2540pen_US
dc.identifier.issn1088-9051-
dc.identifier.issn1549-5469-
dc.identifier.urihttps://genome.cshlp.org/content/22/12/2529-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/53349-
dc.description.abstractThousands of long noncoding RNAs (lncRNAs) have been found in vertebrate animals, a few of which have known biological roles. To better understand the genomics and features of lncRNAs in invertebrates, we used available RNA-seq, poly(A)-site, and ribosome-mapping data to identify lncRNAs of Caenorhabditis elegans. We found 170 long intervening ncRNAs (lincRNAs), which had single- or multiexonic structures that did not overlap protein-coding transcripts, and about sixty antisense lncRNAs (ancRNAs), which were complementary to protein-coding transcripts. Compared to protein-coding genes, the lncRNA genes tended to be expressed in a stage-dependent manner. Approximately 25% of the newly identified lincRNAs showed little signal for sequence conservation and mapped antisense to clusters of endogenous siRNAs, as would be expected if they serve as templates and targets for these siRNAs. The other 75% tended to be more conserved and included lincRNAs with intriguing expression and sequence features associating them with processes such as dauer formation, male identity, sperm formation, and interaction with sperm-specific mRNAs. Our study provides a glimpse into the lncRNA content of a nonvertebrate animal and a resource for future studies of lncRNA function.en_US
dc.description.sponsorshipWe thank Wendy Johnston for technical support, the WI genome technology core for sequencing, David Garcia and Vikram Agarwal for helpful comments on the manuscript, Igor Ulitsky and Nick Burton for helpful discussions, and Paul Davis, Jonathan Hodgkin, and their WormBase colleagues for helpful discussions and inspection of our loci, which helped eliminate false positives from our final lists of lincRNA and ancRNA loci. This work was supported by a grant (GM067031) from the NIH. D.B. is an Investigator of the Howard Hughes Medical Institute.en_US
dc.language.isoenen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.titleLong noncoding RNAs in C. elegansen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume22-
dc.identifier.doi10.1101/gr.140475.112-
dc.relation.page2529-2540-
dc.relation.journalGENOME RESEARCH-
dc.contributor.googleauthorNam, Jin-Wu-
dc.contributor.googleauthorBartel, David P.-
dc.relation.code2012203405-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjwnam-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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