Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지은 | - |
dc.date.accessioned | 2018-03-28T05:43:17Z | - |
dc.date.available | 2018-03-28T05:43:17Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | CLINICAL MICROBIOLOGY AND INFECTION, 2012, 20(11), P.1198-1204 | en_US |
dc.identifier.issn | 1198-743X | - |
dc.identifier.issn | 1469-0691 | - |
dc.identifier.uri | http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)65318-0/fulltext | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/53286 | - |
dc.description.abstract | The purpose of this study was to identify factors associated with relapses or re-infections in patients with recurring Clostridium difficile infections (CDIs). From September 2008 to January 2012, cases with two or more isolates from consecutive CDI episodes were included. PCR-ribotyping and multilocus variable-number tandem-repeat analysis were performed using paired isolates. Among 473 patients, 68 (14.4%) experienced one to five recurrences. Fifty-one of these with two or more isolates from consecutive CDI episodes were included in the study; 25 (49%) were classified as relapses and 26 (51%) as re-infections. Recurrence interval was shorter in the relapse group (26.0 versus 67.5 p0.001), but more patients in the re-infection group were hospitalized during recurrence interval (53.8% versus 8.0%, p<0.001). Relapse rates in infections by ribotype 017, ribotype 018 and other ribotypes were 63.6%, 63.6% and 22.2%, respectively (p0.274, p0.069, and p0.005). In multivariate logistic regression, infections by ribotypes 017 and 018 were associated with CDI relapse (OR 4.77, 95% CI 1.02-22.31, p0.047; OR 11.49, 95% CI 2.07-63.72, p0.005). Conversely, admission during recurrence interval lowered the risk of relapse (OR 0.044, 95% CI 0.006-0.344, p0.003). In conclusion, relapse was more likely when infection was caused by PCR ribotypes 017 and 018. | en_US |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation of Korea (KRF-2011-0014685). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | Clostridium difficile infection | en_US |
dc.subject | multilocus variable-number tandem-repeat analysis | en_US |
dc.subject | PCR ribotyping | en_US |
dc.subject | recurrence | en_US |
dc.subject | re-infection | en_US |
dc.subject | relapse | en_US |
dc.title | Clinical characteristics of relapses and re-infections in Clostridium difficile infection | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 20 | - |
dc.identifier.doi | 10.1111/1469-0691.12704 | - |
dc.relation.page | 1198-1204 | - |
dc.relation.journal | CLINICAL MICROBIOLOGY AND INFECTION | - |
dc.contributor.googleauthor | Kim, J. | - |
dc.contributor.googleauthor | Seo, M. R. | - |
dc.contributor.googleauthor | Kang, J. O. | - |
dc.contributor.googleauthor | Kim, Y. | - |
dc.contributor.googleauthor | Hong, S. P. | - |
dc.contributor.googleauthor | Pai, H. | - |
dc.relation.code | 2014027419 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | quidam76 | - |
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